1. 科研项目

    （1）科技创新2030-“脑科学和类脑研究”重大项目，焦虑障碍新治疗策略的机制研究,2021.12至2026.11，1150.00万元，主持。

    （2） 国家自然科学基金-重大项目，焦虑对神经-内分泌-免疫系统的影响及机制和意义，2021.01至2025.12，562.5万元，参与。

    （3） 国家自然科学基金-重点项目，急性全脑缺血后抑郁的机制和治疗,2019.01至2023.12，293万元，主持。

2. 代表性论文：

 （1） Han J, Kesner P, Metna-Laurent M, Duan T, Xu L, Georges F, Koehl M, Abrous DN, Mendizabal-Zubiaga J, Grandes P, Liu Q, Bai G, Wang W, Xiong L, Ren W, Marsicano G, Zhang X. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. 2012, 48(5): 1039-1050.

   （2）Xue B, Zhang MX, Bi XC, Lai SP, Bie XT, Dong Y, Li JF, Gao F, Zhang X, Wang Y. An Amygdala-hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance. Adv Sci (Weinh). 2025 Jun 16:e05121.

   （3） Xiao Z, Wang X, Zhou N, Yi X, Zhang X, Wu Q, Li Z, Zhang X, Xu H, Xu X. Pde4b-regulated cAMP signaling pathway in the AUDGABA-S1TrSst circuit underlies acute-stress-induced anxiety-like behavior. Cell Rep. 2025, 44(2): 115253.

   （4）Zhang N, Zhao S, Ma Y, Xiao Z, Xue B, Dong Y, Wang Q, Xu H, Zhang X, Wang Y. Hyperexcitation of ovBNST CRF neurons during stress contributes to female-biased expression of anxiety-like avoidance behaviors. Sci Adv. 2024, 10(19): eadk7636

   （5）Zhong H, Tong L, Gu N, Gao F, Lu Y, Xie RG, Liu J, Li X, Bergeron R, Pomeranz LE, Mackie K, Wang F, Luo CX, Ren Y, Wu SX, Xie Z, Xu L, Li J, Dong H, Xiong L, Zhang X. Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice. J Clin Invest. 2017, 127(6): 2295-2309.

   （6）Duan T, Gu N, Wang Y, Wang F, Zhu J, Fang Y, Shen Y, Han J, Zhang X. Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents. J Psychiatry Neurosci. 2017, 42(4): 230-241

   （7）Wang Y, Gu N, Duan T, Kesner P, Blaskovits F, Liu J, Lu Y, Tong L, Gao F, Harris C, Mackie K, Li J, Tan Q, Hill MN, Yuan Z, Zhang X. Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses. Mol Psychiatry. 2017, 22(2): 215-226.

  （8）Ji S, Zhang Y, Van Cleemput J, Jiang W, Liao M, Li L, Wan Q, Backstrom JR, Zhang X. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nat Med. 2006, 12(3): 324-329.

   （9）Jiang W, Zhang Y, Xiao L, Van Cleemput J, Ji S, Bai G, Zhang X. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. J Clin Invest. 2005, 115(11): 3104-3116