中国药理学会生化与分子药理学专业青年委员会委员

四川省医学会泌尿外科专业委员会基础与感染学组委员

中国生物物理学会神经生物物理分会委员

主持/参与项目

1. 国家自然科学基金-面上项目，C9orf72关键调控因子调控原纤毛发生分子机制的研究，2025-01至2028-12，主持

2. 国家自然科学基金-青年项目，EAF对HIV-1前病毒转录调控结构和功能的研究，2023-01至2025-12，主持

3. 四川大学-博士后基金，C9orf72复合体调控膜运输分子机制的研究，2022-01至2023-12，主持

4. 理工医农开发协作项目，磷脂翻转酶高效纯化方法的研究，22H0587，2022-06至2022-07，主持

5. 科技部-国家重点研发计划，分娩启动和早产机理与干预子课题：探讨分娩启动的调控机制， 2018-12至2021-12，第二主研

6. 国家自然科学基金-面上项目，对家族性ALS/FTD 直接相关复合体C9ORF72-SMCR8-WDR41结构和功能的研究，2021-01至2024-12，第一主研

7. 四川省科技厅重点项目，C9orf72以及其蛋白复合体异常导致神经退行性疾病的研究，2022-01至2024-12，第一主研

发表文章

1. Tang, D., Zheng, K., Zhu, J., Jin, X., Bao, H., Jiang, L., Li, H., Wang, Y., Lu, Y., Liu, J., Liu, H., Tang, C., Feng, S., Dong, X., Xu, L., Yin, Y., Dang, S., Wei, X., Ren, H., Dong, B., Dai, L., Cheng, W., Wan, M., Li, Z., Chen, J., Li, H., Kong, E., Wang, K., Lu, K., and Qi, S. (2023). ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis. Proc Natl Acad Sci U S A 120, e2220496120.

2. Tang, D., Sheng, J., Xu, L., Zhan, X., Liu, J., Jiang, H., Shu, X., Liu, X., Zhang, T., Jiang, L., Zhou, C., Li, W., Cheng, W., Li, Z., Wang, K., Lu, K., Yan, C., and Qi, S. (2020c). Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proc Natl Acad Sci U S A 117, 9876-9883.

3. Yuan, Z., Huang, X., Wang, L., Yin, Z., Fu, X., Qi, S., and Tang, D. (2025). The crystal structure of an uncharacterized domain of P113 from Plasmodium falciparum. Acta Crystallogr D Struct Biol 81, 212-222.

4. Tang, D., Bao, H., and Qi, S. (2024). The C9orf72-SMCR8 complex suppresses primary ciliogenesis as a RAB8A GAP. Autophagy 20, 1205-1207.

5. Tang, D., Chen, C., Liao, G., Liu, J., Liao, B., Huang, Q., Chen, Q., Zhao, J., Jiang, H., Duan, J., Huang, J., Wang, K., Wang, J., Zhou, C., Chu, W., Li, W., Sun, B., Li, Z., Dai, L., Fu, X., Cheng, W., Xue, Y., and Qi, S. (2020a). Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription. Cell Discov 6, 7.

6. Tang, D., Sheng, J., Xu, L., Yan, C., and Qi, S. (2020b). The C9orf72-SMCR8-WDR41 complex is a GAP for small GTPases. Autophagy 16, 1542-1543.

7. Feng, S., Huang, X., Tang, D., Liu, X., Ouyang, L., Yang, D., Wang, K., Liao, B., and Qi, S. (2024). The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide. MedComm 5, e479.

8. Li X., Wang P., Zheng K., Qi S., and Tang, D. (2023).The molecular mechanism of Xiaoxuming decoction in the treatment of ischemic stroke. MedComm-Future Medicine 2. E58

9. Lei, Y., Tang, D., Liao, G., Xu, L., Liu, S., Chen, Q., Li, C., Duan, J., Wang, K., Wang, J., Sun, B., Li, Z., Dai, L., Cheng, W., Qi, S., and Lu, K. (2021). The crystal structure of Atg18 reveals a new binding site for Atg2 in Saccharomyces cerevisiae. Cell Mol Life Sci 78, 2131-2143.

10. Yuan, Z., Huang, X., Wang, L., Yin, Z., Fu, X., Qi, S., and Tang, D. (2025). The crystal structure of an uncharacterized domain of P113 from Plasmodium falciparum. Acta Crystallogr D Struct Biol 81, 212-222.