担任国家自然科学基金审稿专家、四川省细胞生物学会青委会副主任等学术任职。

研究涉及溶酶体、内吞体等多个细胞器的新功能及其动态调控机制。作为第一/通讯（含共同）作者身份，在相关领域的 高水平 期刊（Nature Communications、PNAS*2、Plos Biology、iScience、STTT*3等）上发表了十余 篇论文：①解析了Rab32/Rab38 的GEF（HPS1、HPS4）调控黑色素体生成的关键功能和分子机制，揭示了临床上已报道的HPS1、HPS4 突变（22/24）导致赫尔曼斯基-普德拉克综合症（Hermansky-Pudlak syndrome）HPS 的分子机制（Nature Communications，2025）；②揭示了RMC1 在内吞体、溶酶体成熟中的重要功能及调控机制，提出RMC1 可能部分定位于线粒体，为相关罕见病溶酶体贮积症提供了一定科学基础（PNAS，2023）；③发现了内吞体retromer 相关的SNX-BAR 复合物的新功能及调控机制，揭示了高等生物内吞体分选的重要性和复杂性（PNAS，2021；Plos Biology，2020；STTT，2017）。同时，以共同作者在Cell、Cell Research等权威期刊发表多篇论文。获国家自然科学基金、四川省自然科学、博士后科学基金、四川大学“从 0 到 1”创新项目等多个纵向资助。

已发表工作见下：

第一/通讯（含共同）作者发表论文：

1.Yong X，Jia G,et al.Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of

Hermansky-Pudlak syndrome. Nature Communications,(2025) 16:2967.

2.Yong X,Jia G, Liu Z, Zhou C, Yi J, Tang Y, et al. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Proc Natl Acad Sci U S A. 2023;120(22):e2301725120.

3.Yong X,Zhao L, Hu W, Sun Q, Ham H, Liu Z, et al. SNX27-FERM-SNX1 complex structure rationalizes divergent trafficking pathways by SNX17 and SNX27. Proceedings of the National Academy of Sciences. 2021;118(36):e2105510118.

4.Yong X,Zhao L, Deng W, Sun H, Zhou X, Mao L, et al. Mechanism of cargo recognition by retromer-linked SNX-BAR proteins. PLoS biology. 2020;18(3):e3000631.

5.Yong X,Mao L, Seaman MNJ, Jia D. An evolving understanding of sorting signals for endosomal retrieval. iScience. 2022;25(5):104254.

6.Yong X,Zhou C, Billadeau DD, Jia D. Commanding the Commander: structure of a key protein machinery in endosomal trafficking. Signal transduction and targeted therapy. 2023;8(1):295.

7. Sun Q,Yong X, Sun X, Yang F, Dai Z, Gong Y, et al. Structural and functional insights into sorting nexin 5/6 interaction with bacterial effector IncE. Signal transduction and targeted therapy. 2017;2:17030.

8.Yong X,Mao L, Shen X, Zhang Z, Billadeau DD, Jia D. Targeting Endosomal Recycling Pathways by Bacterial and Viral Pathogens. Front Cell Dev Biol. 2021;9:648024.

9.Yong X, Billadeau DD, Jia D. All ways lead to Rome: assembly of retromer on membranes with different sorting nexins. Signal transduction and targeted therapy. 2021;6(1):139.

10.Su Q, Qiao Y, Xiao Y, Yang S, Wu H, Li J, et al. Research progress of 3D printed poly (ether ether ketone) in the reconstruction of craniomaxillofacial bone defects. Front Bioeng Biotechnol. 2023;11:1259696.（通讯作者）

11.Yong X,Hu W, Zhou X, Wang J, Burstein E, Jia D. Expression and purification of the SNX1/SNX6 complex. Protein Expr Purif. 2018;151:93-8.

共同作者发表论文：

1.Deng H,Jia G, et al.The WDR11 complex is a receptor for acidic-clustercontaining cargo proteins.Cell.2024, 187, 1–17.

Zhang S, Gou S, Zhang Q, Yong X, Gan B, Jia D. FSP1 oxidizes NADPH to suppress ferroptosis. Cell Res. 2023;33(12):967-70.

2.Zhao L, Deng H, Yang Q, Tang Y, Zhao J, Li P, et al. FAM91A1-TBC1D23 complex structure reveals human genetic variations susceptible for PCH. Proc Natl Acad Sci U S A. 2023;120(45):e2309910120.

3.Huang W, Liu Z, Yang F, Zhou H, Yong X, Yang X, et al. Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH. Proc Natl Acad Sci U S A. 2019;116(45):22598-608.

4.Zhao L, Zhong K, Zhao J, Yong X, Tong A, Jia D. SARS-CoV-2 spike protein harnesses SNX27-mediated endocytic recycling pathway. MedComm (2020). 2021;2(4):798-809.