研究员、药理学博士、博导,四川大学华西公共卫生学院(华西第四医院)院长助理,药物/器械临床试验机构副主任,国家“863”计划青年科学家项目课题获得者、四川省“卫生健康英才计划”首席专家、四川大学“好未来青年学者”。主要从事肿瘤及组织纤维化疾病的发生进展机制与靶向治疗药物研究,相关研究成果在J Control Release, Acta Pharmaceutica Sinica B, Signal Transduction and Targeted Therapy, Journal of hazardous materials, Advanced Science等发表高水平国际期刊论文70余篇,第一和通讯30余篇;申请国家发明专利21项,获授权11项,转让4项。作为负责人承担国家“863”计划课题(2015)、“重大新药创制”国家科技重大专项课题(2019)、国家重点研发计划课题(2023)、国家自然科学基金青年(2015)及面上(2018,2024)等项目6项,其他省部级及横向项目10余项。
四川省医学会职业病学专业委员会候任主委;
四川省预防医学会理事;
四川省干细胞技术与细胞治疗协会常务理事
中国毒理学会表观遗传毒理专委会委员
中国毒理学会免疫毒理专业委员会委员
《现代预防医学》杂志常务编委
《中华疾病控制杂志》青年编委
以第一或通讯作者身份在J Control Release, Acta Pharmaceutica Sinica B, Signal Transduction and Targeted Therapy, Journal of hazardous materials, Advanced Science等杂志发表高水平国际期刊论文论文20余篇,1篇入选ESI高被引论文:
1. Wang L, Chen X, Quan H, Qian R, Gong S, He Q, Gao Y, Axi A, Zhao M, Zhang Q, Zhang L, Peng L, Sun X, Zhang B, Yao Y*. Macrophage-Derived Ferritin Exacerbates Silica-Induced Pulmonary Fibrosis via PIK3R2-Mediated Fibroblast Differentiation. Advanced Science. 2026 Mar;13(17):e19191.
2. Zhao M, Chen Q, Chen X, Gong S, Wang M, Zhao S, Wang S, Du W, Xu Y, Peng L*,Yao Y*. Tripartite motif-containing 32 regulated by miR-6236-p5 inhibited silica-induced apoptosis of alveolar macrophages. Toxicology. 2025 Feb; 511:154042.
3. Zhao M, Wang M, Chen X, Gao Y, Chen Q, Wang L, Bao Q, Sun D, Du W, Xu Y, Xie L, Jiang X, Zhang L, Peng L, Zhang B*,Yao Y*: Targeting progranulin alleviated silica particles-induced pulmonary inflammation and fibrosis via decreasing Il-6 and Tgf-β1/Smad.Journal of hazardous materials2023, 465:133199.
4. Xu Y, Wang L, Qian R, Zhao M, Chen X, Sun D, Wang Y, Cheng W, Chen Y, He Q, Dai Y*, Yao Y*: Increased m6A-RNA methylation and demethylase FTO suppression is associated with silica-induced pulmonary inflammation and fibrosis. Toxicology 2023, 500:153673.
5. Liu L, Zhang L, Chen X, Yang K, Cui H, Qian R, Zhao S, Wang L, Su X, Zhao M, Wang M, Hu Z, Lu T, Zhu Y, Zhou QQ*, Yao Y*: Design and synthesis of 1H-benzo[d]imidazole selective HDAC6 inhibitors with potential therapy for multiple myeloma.European journal of medicinal chemistry 2023, 261:115833.
6. Zhao M, Wang L, Wang M, Zhou S, Lu Y, Cui H, Racanelli AC, Zhang L, Ye T, Ding B, Zhang B, Yang J*, Yao Y*: Targeting fibrosis, mechanisms and clinical trials. Signal transduction and targeted therapy 2022, 7:206.
7. Zhao M, Wang L, Wang M, Bao Q, Qian R, Peng L, Fang A, Du W, Xie L, Zhang Z, Yao Y*, Zhang B*: Alveolar macrophage-derived progranulin mediated pro-inflammatory Il-6 expression via regulating Creb1 in silicosis model. Int Immunopharmacol 2022, 107:108705.
8. Wang L, Zhao M, Qian R, Wang M, Bao Q, Chen X, Du W, Zhang L, Ye T, Xie Y, Zhang B, Peng L*,Yao Y*: Nicotinamide Mononucleotide Ameliorates Silica-Induced Lung Injury through the Nrf2-Regulated Glutathione Metabolism Pathway in Mice. Nutrients 2022, 15.
9. Yao Y, Liu Z, Zhao M, Chen Z, Li P, Zhang Y, Wang Y, Zhao C, Long C, Chen X, Yang J: Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy. Acta pharmaceutica Sinica B 2020, 10:1453-75.
10. Lai Q, Wang Y, Wang R, Lai W, Tang L, Tao Y, Liu Y, Zhang R, Huang L, Xiang H, Zeng S, Gou L, Chen H*, Yao Y*, Yang J: Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.European journal of medicinal chemistry 2018, 156:162-79.
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