聂春来，男，教授，博士生导师，1995-1999年毕业于四川大学生命科学学院生物化学专业，获理学学士学位。同年考上中国科学院生物物理研究所脑与认知中心国家重点实验室，攻读博士学位， 从事老年性痴呆的分子机理研究，2004年7月获理学博士。9月进入中国科学院动物研究所博士后流动站，在生物膜与膜生物国家重点实验室从事细胞凋亡和抗癌药物机理研究。2007年进入四川大学生物治疗国家重点实验室从事抗癌药物应用性基础研究，主要研究肿瘤相关疾病的免疫调控，发病机理和相关抗体的生产和制备。以第一作者身份或通讯作者身份在高水平杂志J Control Release, Adv Sci, Biomolecules, Cell death&disease, JBC, Mol Med和Plos one等上发表多篇文章，在抗癌药物研究中具有重要基础。
JCMM, FEBS L, Plos one，BBA, CDDies, Int J Gynecol Cancer特邀审稿人
【代表性论著】
1. Zhixiong Zhu, Shuqin Cao, Hanwen Li, Zongliang Zhang, Qizhong Lu, Hexian Li, Luxuan Shen, Zeng Wang, Nian Yang, Jiayun Yu, Jianshu Li, Meijun Zheng, Chunlai Nie(*), Aiping Tong*, Bin Shao*. Myeloid-derived suppressor cell-targeted virus-like particles synergistically activate innate immune response for cancer immunotherapy. J Control Release. 2025 May 10:381:113603.
2. Zhixiong Zhu, Hexian Li, Qizhong Lu, Zongliang Zhang, Jia Li, Zeng Wang, Nian Yang, Zhengyu Yu , Chen Yang, Yongdong Chen, Huaqing Lu, Wei Wang , Ting Niu , Chunlai Nie(*), Aiping Tong*. mRNA-Engineered CD5-CAR-γδTCD5- Cells for the Immunotherapy of T-Cell Acute Lymphoblastic Leukemia. Adv Sci (Weinh). 2024 Sep;11(35):e2400024.
3. Mei Tang, Caili Chen, Guoqing Wang, Yuelong Wang, Zongliang Zhang, Hexian Li, Qizhong Lu, Zeng Wang, Shasha Zhao, Chen Yang, Kunhong Zhong, Ruyuan Zhang, Liping Guo, Zhu Yuan, Chunlai Nie(*), Aiping Tong*. Evaluation of B7-H3 Targeted Immunotherapy in a 3D Organoid Model of Craniopharyngioma. Biomolecules. 2022 Nov 24;12(12):1744.
4. Chao Zeng, Zhixuan Zhang, Wei Luo, Liyang Wang, Hang Zhou*, Chunlai Nie(*). JNK initiates Beclin-1 dependent autophagic cell death against Akt activation. Exp Cell Res. 2022 May 15;414(2):113105.
5. Yu Zhang, Hang Zhou, Yongjun Tao, Xingyu Liu, Zhu Yuan and Chunlai Nie(*). ARD1 contributes to IKKβ-mediated breast cancer tumorigenesis. Cell Death Dis. 2018, 9(9):860.
6. Juan Zhang*, Yu Zhang, Wenshuang Wu, Fang Wang, Xinyu Liu, Guanghou Shui and Chunlai Nie(*).Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion. Cell Death Dis. 2017,8(10):e3151.
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