何光林,四川大学考古科学中心/四川大学华西医院特聘副研究员,“人类遗传与法医基因组学”课题组组长,四川省耳鼻喉大数据研究专委会副主任委员、四川省医学会医学遗传学专委会青年委员会副主任委员,四川省医学会医学遗传学专委会委员。从事大人群基因组学研究。作为核心发起人牵头组织中国万人基因组多样性计划(10K_CPGDP)与炎黄队列(YHC)。主持国家自然科学基金、国家社科基金重大项目子课题等7项课题。研究成果《中国人群精细遗传结构与法医学应用研究》获2021年贵州省医学科技一等奖;多篇论文入选高被引或期刊亮点文章,于2020至2025年连续六年入选斯坦福大学“全球前2%顶尖科学家榜单(法医学领域)”。
担任BMC Biology、Exploration、Research、Science Bulletin等SCI期刊副主编或(青年)编委。
近五年,以通讯作者(含共同)在Science Advances(2025, 2026a/b)、Molecular Biology and Evolution(2024, 2025a/b)、Advanced Science(2026a/b/c)、Genome Biology(2025)、Science China Life Sciences(2025a/b)、Genomics, Proteomics & Bioinformatics(2025a/b)、Journal of Genetics and Genomics(2024, 2025a/b/c)、BMC Biology(5篇)、Journal of Systematics and Evolution(6篇)、European Journal of Human Genetics 等国际高水平期刊发表论文50余篇。其中,在法医学领域权威期刊 Forensic Science International: Genetics 发表论文8篇,在 International Journal of Legal Medicine 发表论文9篇。
近5年代表性成果
[1] He Guanglin#,*, Wang Zhiyong*, ……, Liu Chao, Yuan Huijun*, Wang Mengge*. Complex Peopling History and Expansion Events Inferred from Large-Scale Modern and Ancient Y-Chromosome Sequences. Science Advances, 2026a.(IF(5) 14.1;IF 12.5;JCR Q1,中科院1区;唯一第一作者,并为共同通讯作者)
[2] Wang Mengge#,*, Liu Yunhui#, Luo Lintao#, Wang Zhiyong#, Feng Yuhang#, ……, Tang Renkuan*, He Guanglin*. Multiple southward migrations of Neolithic Chinese farmers into Southeast Asia revealed from large-scale Y-chromosome sequences. Science Advances, 2026b, 12(8): eady1597. (IF(5) 14.1;IF 12.5;JCR Q1,中科院1区;最后通讯作者)
[3] Huang Yuguo#, Wang Mengge#, ……, Liu Chao, Lu Yu*, Cheng Jing*, Bu Fengxiao*, He Guanglin*, Yuan Huijun*. Short tandem repeats in populations of the Qinghai-Tibet Plateau and adjacent regions provide insights into high-altitude adaptation. Science Advances, 2025, 11(42): eadx1590.(IF(5) 14.1;IF 12.5;JCR Q1,中科院1区;共同通讯作者)
[4] Liu Yunhui#, ……, Liu Chao*, Tang Renkuan*, Wang Mengge#,*, He Guanglin#,*. Modern and Ancient Genomes Reveal Neolithic Paternal Expansions of Millet and Rice Farmers and Demic Diffusion from China into Mainland Southeast Asia. Advanced Science, 2026: e15930.(IF(5) 15.6;IF 14.1;JCR Q1,中科院1区;共同第一作者,最后通讯作者)
[5] Mengge Wang#,*, Shuhan Duan*, Qiuxia Sun*, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium, Lan-Hai Wei#, Chao Liu#, Maxat Zhabagin#, He Guanglin#,*. Whole-genome sequencing pilot of the Central Asian Genomic Diversity Project reveals distinct histories, adaptation, and introgression [J]. Advanced Science, 2026. (IF(5) 15.6;IF 14.1;JCR Q1,中科院1区;共同第一作者,最后通讯作者)
[6] Yang L., Zhang C., Lyu M., Luo Y., Zhang J., Chen Y., Luo L., Qiao W., Li X., Zhou Y., Wei Z., Xiao Y., Niu Q., Zhou J., He Guanglin#, Ying B.#, Su Z.#, Chen H.#, Tang X.#, Dong H#. Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance [J]. Advanced Science, 2026, n/a(n/a): e76081.(IF(5) 15.6;IF 14.1;JCR Q1,共同通讯作者)
[7] Wang Mengge#,*, Huang Yuguo#, ……, Zhu Bofeng*, Liu Chao*, He Guanglin#,*. Multiple Human Population Movements and Cultural Dispersal Events Shaped the Landscape of Chinese Paternal Heritage. Molecular Biology and Evolution, 2024, 41(7): msae122.(IF(5) 11.9;IF 11.08;JCR Q1,中科院1区;共同第一作者,最后通讯作者)
[8] He Guanglin*, Chen Jing*, Duan Shuhan*, Yang Qingxin*, ……, 10K_CPGDP Consortium, Yuan Haibing*, Yuan Huijun*, Liu Chao*, Wang Mengge*. Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People. Molecular Biology and Evolution, 2025a, 42(10): msaf225.(IF(5) 11.9;JCR Q1,中科院1区;唯一第一作者,并为共同通讯作者)
[9] He Guanglin*, Duan Shuhan*, ……, Liu Chao*, Yuan Huijun*, Wang Mengge*. Human Population Genetic History and Evolutionary Dynamics on the Eastern Tibetan Plateau. Molecular Biology and Evolution, 2025b, 42(11): msaf258.(IF(5) 11.9;JCR Q1,中科院1区;唯一第一作者,并为共同通讯作者)
[10] He Guanglin*, Sun Yuntao*, Duan Shuhan*, ……, Yun Libing*, Liu Chao*, Wang Mengge*. Ancient genomes give insight into 160,000 years of East Asian population dynamics and biological adaptation. Genome Biology, 2025, 26(1): 420.(IF(5) 16.3;IF 9.4;JCR Q1,中科院1区;唯一第一作者,并为共同通讯作者)
[11] Yang Qingxin*, ……, Deng Hong#, Wang Mengge#, He Guanglin#,*. High-quality population-specific haplotype-resolved reference panel in the genomic and pangenomic eras. Genomics Proteomics & Bioinformatics, 2025a.(IF(5) 9.1;IF 11.5;JCR Q1,中科院1区;共同第一作者,最后通讯作者)
[12] Wang Zhiyong*, ……, Nie Shengjie#, Liu Chao#, Wang Mengge#,*, He Guanglin#,*. YanHuang paternal genomic resource suggested a Weakly-Differentiated Multi-Source Admixture model for the formation of Han's founding ancestral lineages. Genomics Proteomics & Bioinformatics, 2025b.(IF(5) 9.1;IF 11.5;JCR Q1,中科院1区;共同第一作者,最后通讯作者,高被引论文)
[13] He Guanglin*, ……, Liu Chao*, Wang Mengge*. Pilot work of the 10K Chinese People Genomic Diversity Project along the Silk Road suggests a complex east‒west admixture landscape and biological adaptations. Science China Life Sciences, 2025a, 68(4): 914-933.(IF 9.5;JCR Q1,中科院1区,高被引;唯一第一作者,并为共同通讯作者)
[14] Luo Lintao#, Wang Mengge#,*, Liu Yunhui#, ……, Yuan Huijun*, Tang Renkuan*, Liu Chao*, He Guanglin#,*. Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm. Science China Life Sciences, 2025b, 68(6): 1610-1625.(IF 9.5;JCR Q1,中科院1区,高被引;共同第一作者,最后通讯作者,高被引论文)
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