杨万纯,副研究员/硕士生导师。2008年于四川大学生命科学学院获理学学士学位;2014年于四川大学生物治疗国家重点实验室获生物学博士学位。2014年至2021年先后在四川大学生物治疗国家重点实验室和华西医院开展博士后研究工作;2022年至今在四川大学华西医院神经外科研究所开展中枢神经系统发育和肿瘤发生的相关研究工作。
中国神经生物学学会会员及多个国外高水平期刊审稿人。
从胶质细胞和细胞代谢角度,开展中枢神经系统发育和肿瘤发生的相关基础研究工作,以第一或通讯作者(共同)身份在Developmental Cell等国际主流期刊发表论文二十余篇。现主持国家自然科学基金面上项目及四川省自然科学基金等多项课题。
部分代表性论文:
1) Yang, W., D. Pang, M. Chen, C. Du, L. Jia, L. Wang, Y. He, W. Jiang, L. Luo, Z. Yu, M. Mao, Q. Yuan, P. Tang, X. Xia, Y. Cui, B. Jing, A. Platero, Y. Liu, Y. Wei, P. F. Worley and B. Xiao (2021). "Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation." Dev Cell.
2) Jia, L., M. Liao, A. Mou, Q. Zheng, W. Yang, Z. Yu, Y. Cui, X. Xia, Y. Qin, M. Chen and B. Xiao (2021). "Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability." Dev Cell.
3) Xiang, Y., B. Wang, W. Yang, X. Zheng, R. Chen, Q. Gong, Z. Gu, Y. Liu and K. Luo (2024). "Mitocytosis Mediated by an Enzyme-Activable Mitochondrion-Disturbing Polymer-Drug Conjugate Enhances Active Penetration in Glioblastoma Therapy." Adv Mater.
4) Yuan, Q., M. Mao, X. Xia and W. Yang (2024). "Clinical and prognostic significance analysis of glycolysis-related genes in HNSCC." J Gene Med.
5) Qi, X., Q. Yuan, X. Xia, W. Li, M. Cao and W. Yang (2023). "Clinical and molecular analysis of cilia-associated gene signature for prognostic prediction in glioma." J Cancer Res Clin Oncol.
6) Mao, M., Q. Yuan, X. Xia, Y. Cui, M. Chen and W. Yang (2023). "Integrative analysis defines DDIT3 amplification as a correlative and essential factor for glioma malignancy." Am J Cancer Res.
7) Du, C., W. Yang, Z. Yu, Q. Yuan, D. Pang, P. Tang, W. Jiang, M. Chen and B. Xiao (2022). "Rheb Promotes Triglyceride Secretion and Ameliorates Diet-Induced Steatosis in the Liver." Frontiers in Cell and Developmental Biology.
8) Yang, W., Q. Yuan, S. Zhang, M. Zuo, T. Li, J. Li, X. Zhou, M. Li, W. Feng, X. Xia, M. Chen and Y. Liu (2021). "Elevated GIGYF2 expression suppresses tumor migration and enhances sensitivity to temozolomide in malignant glioma." Cancer Gene Therapy.
9) Yuan, Q., W. Yang, S. Zhang, T. Li, M. Zuo, X. Zhou, J. Li, M. Li, X. Xia, M. Chen and Y. Liu (2021). "Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma." Mol Med.
10) Yuan, Q., M. Chen, W. Yang and B. Xiao (2021). "Circadian Rheb oscillation alters the dynamics of hepatic mTORC1 activity and mitochondrial morphology." FEBS Lett.
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