中国医药生物技术协会会员

1、 科研项目：

（1）国家自然科学基金-面上项目，免疫增效和淋巴器官靶向新型多肽佐剂KK2DP7在抗肿瘤&抗感染疫苗中的作用和机制研究，2025-01至2028-12，47万元，主持

（2）国家自然科学基金-青年基金：基于多组学测序研究多肽DP7-C通过调控代谢产物促进DC迁移、提高DC疫苗效果的机制；30万；2022.1-2024.12，主持

（3）四川省科技厅青年基金：免疫调节肽DP7-C调控代谢产物促进DC归巢、提高DC疫苗效果的机制研究；10万；2022.1-2023.12，结题，主持

（4）国家重点研发计划：肿瘤新抗原筛选技术以及纳米疫苗开发；2024.1-2025.12，在研，任务3负责人，任务经费98万

（5）科技部国家重点研发计划：广谱双组份多价重组蛋白新冠疫苗的研发及产业化研究（JM），2022.10-2023.10，250万元；结题，参与。

（6）中国博士后科学基金-博士后站前特别资助：基于胆固醇修饰的阳离子多肽（DP7-C）设计的可电离脂质体用于mRNA肿瘤疫苗的抗肿瘤效果及机制研究；18万；2020.9-2023.9，结题，主持

（7）中国博士后科学基金-博后面上项目：探究不同给药时间表下不同新抗原疫苗免疫形式及其联合PD-1单抗的免疫应答规律和抗肿瘤效果；8万，2021.10-2023.9，结题，主持

2、 科研论文（第一/共同第一/共同通讯）：

(1) Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, and Li Yang*. KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti-Tumor Therapy. Advance Science. 2025, 2500032(2) Rui Zhang; Lin Tang, Yusi Wang, Yaomei Tian, Siwen Wu, Bailing Zhou, Chunyan Dong, Binyan Zhao, Yuling Yang, Daoyuan Xie, Li Yang*. A dendrimer peptide (KK2DP7) delivery system with dual functions of lymph node targeting and immune adjuvants as a general strategy for cancer immunotherapy. Advanced Science. 2023, 10, 2300116.  

(3) Zhenyu Ding^#; Qing Li^#; Rui Zhang^#; Li Xie; Yang Shu; Song Gao; Peipei Wang; Xiaoqing Su; Yun Qin; Yuelan Wang; Juemin Fang; Zhongzheng Zhu; Xuyang Xia; Guochao Wei; Hui Wang; Hong Qian; Xianling Guo; Zhibo Gao; Yu Wang; Yuquan Wei; Qing Xu*; Heng Xu*; Li Yang*; Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer, Signal Transduction and Targeted Therapy, 2021, 6(1): 26.

(4)Rui Zhang; Xiaohua Jiang; Jingxin Qiao; Zeng Wang; Aiping Tong; Jinliang Yang; Shengyong Yang; Li Yang*; Antimicrobial peptide DP7 with potential activity against SARS coronavirus infections, Signal Transduction and Targeted Therapy, 2021, 6(1): 140. (5) Rui Zhang; Lin Tang; Yaomei Tian; Xiao Ji; Qiuyue Hu; Bailing Zhou; Ding Zhenyu; Heng Xu; Li Yang*; Cholesterol-modified DP7 enhances the effect of individualized cancer immunotherapy based on neoantigens, Biomaterials, 2020, 241: 119852.

(6) Rui Zhang; Lin Tang; Yaomei Tian; Xiao Ji; Qiuyue Hu; Bailing Zhou; Zhenyu Ding; Heng Xu; Li Yang*; DP7-C-modified liposomes enhance immune responses and the antitumor effect of a neoantigen-based mRNA vaccine, Journal of Controlled Release, 2020, 328: 210-221.

(7) Lin Tang^#, Rui Zhang^#, Yusi Wang, Mohan Liu, Die Hu, Yefeng Wang, Li Yang*. A blood–brain barrier- and blood–brain tumor barrier-penetrating siRNA delivery system targeting gliomas for brain tumor immunotherapy, Journal of Controlled Release, 2024, 369: 642-657.

(8) Lin Tang#; Rui Zhang#*; Yusi Wang; Xiaoyu Zhang; Yuling Yang; Binyan Zhao; Li Yang*; A simple self-assembly nanomicelle based on brain tumor-targeting peptide-mediated siRNA delivery for glioma immunotherapy via intranasal administration, Acta Biomaterialia, 2023, 155: 521-537

(9) Hongyou Zhou*, Rui Zhang*, Ke Men, Lin Tang, Yusi Wang, Li Yang. A Novel Systemic siDR6 Delivery System Based on DP7-C for the Treatment of Metastatic Lung Cancer. International Journal of Nanomedicine. 2025:20 3623–3642

(10) Rui Zhang^#; Fengjiao Yuan^#; Yang Shu; Yaomei Tian; Bailing Zhou; Linglu Yi; Xueyan Zhang; Zhenyu Ding; Heng Xu; Li Yang*; Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models, Cancer Immunology, Immunotherapy, 2020, 69(1): 135-145.

(11) Rui Zhang^#; Fengbo Wu^#; Lei Wu; Yaomei Tian; Bailing Zhou; Xueyan Zhang; Rong Huang; Chaoheng Yu; Gu He*; Li Yang*; Novel Self-Assembled Micelles Based on Cholesterol-Modified Antimicrobial Peptide (DP7) for Safe and Effective Systemic Administration in Animal Models of Bacterial Infection, Antimicrobial Agents and Chemotherapy, 2018, 62(11): e00368-18.

(12) Rui Zhang^#; Zhenling Wang^#; Yaomei Tian; Qi Yin; Xingjun Cheng；Mao Lian; Bailing Zhou; Xueyan Zhang; Li Yang*; Efficacy of Antimicrobial Peptide DP7, Designed by Machine-Learning Method, Against Methicillin-Resistant Staphylococ- cus aureus, Frontiers in Microbiology, 2019, 10.

(13) Rui Zhang^#; Lin Tang^#; Binyan Zhao; Yaomei Tian; Bailing Zhou; Yandong Mu; Li Yang*; A Peptide-Based Small RNA Delivery System to Suppress Tumor Growth by Remodeling the Tumor Microenvironment, Molecular pharmaceutics, 2021, 18: 1431-1443.

(14) Rui Zhang^#; Ke Men^#; Xueyan Zhang; Rong Huang; Yaomei Tian; Bailing Zhou; Chaoheng Yu; Yantai Wang; Xiao Ji; Qiuyue Hu; Li Yang*; Delivery of a Modified mRNA Encoding IL-22 Binding Protein (IL-22BP) for Colon Cancer Gene Therapy, Journal of Biomedical Nanotechnology, 2018, 14(7): 1239-1251.

(15) Ke Men^#*;Rui Zhang^#; Xueyan Zhang; Rong Huang; Guonian Zhu; Rongsheng Tong; Li Yang; Yuquan Wei; Xingmei Duan*; Delivery of modified mRNA encoding vesicular stomatitis virus matrix protein for colon cancer gene therapy, RSC Advances, 2018, 8(22): 12104-12115.

(16) Lin Tang^#, Rui Zhang^#, Xiaoyu Zhang and Li Yang*; Personalized Neoantigen- Pulsed DC Vaccines: Advances in Clinical Applications, Frontiers in Oncology, 2021, 11, 701777.

(17) Rui Zhang#, Lin Tang#, Qing Li, Yaomei Tian,Binyan Zhao, Bailing Zhou, Li Yang*; Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines, Molecular Biomedicine, 2021,2:37.

(18) Yusi Wang#, Rui Zhang#, Lin Tang and Li Yang*; Nonviral Delivery Systems of mRNA Vaccines for Cancer Gene Therapy, Pharmaceutics, 2022, 14, 512.

(19)Rui Zhang, Lin Tang, Yusi Wang, Qing Li, Li Yang*; α-D-Glu-1,6-biphosphate induces DC homing to enhance the antitumor effect of neoantigen vaccines. Journal of Immunology. 2023, 211(6):932-943.