中国抗癌协会肿瘤标志专业委员会委员

1.论文

Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells. Cell Stem Cell, 31(8):1203,2024

Multicellular ecotypes shape progression of lung adenocarcinoma from ground-glass opacity toward advanced stages. Cell Reports Medicine, 5(4):101489,2024

Oncofetal protein glypican-3 is a biomarker and critical regulator of function for neuroendocrine cells in prostate cancer. Journal of Pathology, 260(1):43-55,2023

Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy. European Urology 81(5):446,2022

An age-independent gene signature for monitoring acute rejection in kidney transplantation. Theranostics 10(15):6977, 2020

ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer. OncoImmunology 9(1): 1758003, 2020

Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Science Translational Medicine 11(521):eaax0428,2019

A novel integrative risk Index of Papillary Thyroid Cancer progression combining genomic alterations and patient-related demographic and clinical factors. Oncotarget 8(10): 16690, 2017

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. Science Translational Medicine 8:340ra73, 2016

Overexpression of the EMT Driver Brachyury in Breast Carcinomas: Association with Poor Prognosis. Journal of the National Cancer Institute 106: ju054, 2014

A signature of epithelial mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype. Breast Cancer Research 16:407, 2014

Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. Breast Cancer Research 14:R62, 2012

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nature Medicine 17:1298, 2011

Epigenetic regulation of human r-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. American Journal of Human Genetics 79:264, 2006

Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. Nature Genetics 37:878, 2005

Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics. Journal of Clinical Investigation 115:110, 2005

2.专利

Biomarkers for the Identification of Aggressive Prostate Cancer and Methods of Treatment Thereof（WO 2023/122579 A2）

Gene Signatures for Monitoring Acute Rejection and Methods of Using Same（US 2021/0340269 A1）

Genotyping Assay to Predict Gamma Glutamyl Hydrolase (GGH) Activity (US 2012/0178087 A1)