中国老年学和老年医学学会理事，中国细胞生物学会理事

主要研究方向：

 （1）成体干细胞功能调控、衰老及肿瘤化发生的机制。

 （2）代谢在组织损伤修复及稳态维持的作用及调控机制。

 （3）代谢及衰衰老相关疾病研究。

 （4）代谢及衰老疾病的药物筛选及其机制研究。

 主持或参与的科研项目：

国家科技部重点研发项目，2020YFA0803602，调控代谢可塑性和代谢记忆形成的信号通路及表观遗传机制，2020/12-2025/11，主持（课题负责人）。

国家自然科学基金面上项目，32470879，极长链脂肪酸通过调控肠道干细胞中过氧化物酶体稳态促进肠道粘膜修复的机制研究，2025/01-2028/12，主持。

国家科技创新2030，SQ2023AAA031917，垂体激素对糖脂代谢的时空网络调控机制及临床转化策略，2023/12-2027/11，参与（课题骨干）。

四川省自然科学基金面上项目，2025ZNSFSC0720，脂肪肝分泌溶血磷脂酰胆碱抑制肠干细胞功能和肠粘膜损伤修复的作用机制研究，2025/01-2026/12，主持。

国家自然科学基金重大研究计划培育项目，92157109，脂肪细胞来源A-FABP调控肠道干细胞分化及肠粘膜损伤修复的机制研究，2022/01-2024/12，主持。

国家自然科学基金重大研究计划培育项目，91749110，线粒体Sirtuin4不对称分配介导的干细胞行为对器官衰老的作用和调控机制研究，2018/01-2020/12，主持。

中组部第十三批国家青年人才项目，2017年，生命科学，主持。

国家自然科学基金优秀青年项目，31622031，个体衰老的细胞及分子机理研究，2016年，主持。

国家自然科学基金面上项目，31671254，衰老过程中Lamin-B Receptor蛋白聚积通过扰乱干细胞竞争促进生殖干细胞丢失的分子机制研究，2017/01-2020/12，主持。

国家科技部重点研发项目，2018YFA0108301，干细胞外泌体调控中枢神经系统功能修复的机制和转化研究，2018/07-2023/06,参与（课题骨干）。

广东省杰出青年项目，衰老的分子机制研究方向，2016年，生命科学，主持。

代表性论文（*通讯作者）：

Zehong Zhang^#, Qianyi Wan^#, Yuedan Zhu^#, Jinbao Ye^#, Fang Fu, Xinxin Fan, Haiou Chen, Gang Ren, Wei Jiang, Xiaoxin Guo, Juanyu Zhou, La Yan, Jinhua Yan, Xingzhu Liu, Yu Yuan, Yi Chen*, Haiyang Chen*; Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging, Nature Communications, 2025 Accepted (期刊论文) (本人标注:共同通讯作者)

Zhiming Liu^#, Gang Du^#, Yi Chen*, Haiyang Chen*; Age-associated Decline of Coenzyme A leads to Intestinal stem cells dysfunction via disturbing iron homeostasis, Plos Genetics, 2025 Accepted (期刊论文) (本人标注:共同通讯作者)

Kun Wu^#, Juanyu Zhou^#, Yiming Tang^#, Qiaoqiao Zhang^#, Lishou Xiong^#, Xiaorong Li, Zhangpeng Zhuo, Mei Luo, Yu Yuan, Xingzhu Liu, Zhendong Zhong, XiaoXin Guo, Zihua Yu, Xiao Sheng, Guanzheng Luo, Haiyang Chen*; Werner syndrome exonuclease promotes gut regeneration and causes age-associated gut hyperplasia in Drosophila, Plos Biology, 2025, 23(4): e3003121 (期刊论文) (本人标注:唯一通讯作者)

Ting Luo^#, Liusha Zhao^#, Chenxi Feng^#, Jinhua Yan, Yu Yuan, Haiyang Chen*; Asparagine prevents intestinal stem cell aging via the autophagy-lysosomal pathway, Aging Cell, 2024, e14423(期刊论文) (本人标注:唯一通讯作者)

Chenxi Feng^#, Jinhua Yan^#, Ting Luo^#, Hong Zhang, Hu Zhang, Yu Yuan, Yi Chen*, Haiyang Chen*. Vitamin B12 ameliorates gut epithelial injury via modulating the HIF-1 pathway and gut microbiota. Cellular and Molecular Life Sciences, 2024, 81(1): 397 (期刊论文) (本人标注:共同通讯作者)

Zihua Yu^#; Yuedan Zhu^#; Yi Chen^#; Chenxi Feng^#; Zehong Zhang; Xiaoxin Guo; Haiou Chen; Xingzhu Liu; Yu Yuan; Haiyang Chen*; Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction, Nature Communications, 2024, 15(1): 9243 (期刊论文) (本人标注:唯一通讯作者)

Qianyi Wan^#; Xingzhu Liu^#; Jinghao Xu; Rui Zhao; Shiqin Yang; Jianrong Feng; Zhan Cao; Jingru Li; Xiaopeng He; Haiou Chen; Jinbao Ye; Haiyang Chen*; Yi Chen*; Body Composition and Progression of Biopsy-Proven Non-Alcoholic Fatty Liver Disease in Patients With Obesity, Journal of Cachexia, Sarcopenia and Muscle, 2024, 15(6): 2608-2617 (期刊论文) (本人标注:共同通讯作者)

Xiaoxin Guo^#; Juanyu Zhou^#; La Yan^#; Xingzhu Liu; Yu Yuan; Jinbao Ye; Zehong Zhang; Haiou Chen; Yongxin Ma; Zhendong Zhong; Guanzheng Luo; Haiyang Chen*; Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration, Developmental Cell, 2024, 59: 1–17 (期刊论文) (本人标注:唯一通讯作者)

Jinbao Ye^#; La Yan^#; Yu Yuan^#; Fang Fu; Lu Yuan; Xinxin Fan; Juanyu Zhou; Yuedan Zhu; Xingzhu Liu; Gang Ren*; Haiyang Chen*; Natural flavonoid glycosides Chrysosplenosides I & A rejuvenate intestinal stem cell aging via activation of PPARγ signaling, Life Medicine, 2024, 3(3): lnae025 (Cover story) (期刊论文) (本人标注:共同通讯作者)

Qiaoqiao Zhang^#; Kai Deng; Mengyou Liu; Shengye Yang; Wei Xu; Tong Feng; Minwen Jie; Zhiming Liu; Xiao Sheng; Haiyang Chen*; Hao Jiang*; Phase separation of BuGZ regulates gut regeneration and aging through interaction with m6A regulators, Nature Communications, 2023, 14(1): 6700 (期刊论文) (本人标注:共同通讯作者)

Juanyu Zhou^#; Li He^#; Mengyou Liu^#; Xiaoxin Guo; Gang Du; La Yan; Zehong Zhang; Zhendong Zhong; Haiyang Chen*; Sleep loss impairs intestinal stem cell function and gut homeostasis through the modulation of the GABA signalling pathway in Drosophila, Cell Proliferation, 2023, 56(9): e13437 (期刊论文) (本人标注:唯一通讯作者)

La Yan^#; Xiaoxin Guo^#; Juanyu Zhou; Yuedan Zhu; Zehong Zhang; Haiyang Chen*;Quercetin Prevents Intestinal Stem Cell Aging via Scavenging ROS and Inhibiting Insulin Signaling in Drosophila, Antioxidants (Basel),2022, 12(1): 592 (期刊论文) (本人标注:唯一通讯作者)

Jinping Huang^#; Xiao Sheng^#; Zhangpeng Zhuo; Danqing Xiao; Kun Wu; Gang Wan*; Haiyang Chen*; ClC-c regulates the proliferation of intestinal stem cells via the EGFR signalling pathway in Drosophila, Cell Proliferation, 2022, 55(1): e13173 (期刊论文) (本人标注:共同通讯作者)

Kun Wu^#; Yiming Tang^#; Qiaoqiao Zhang^#; Zhangpeng Zhuo; Xiao Sheng; Jingping Huang; Jie'er Ye; Xiaorong Li; Zhiming Liu; Haiyang Chen*; Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila, PLOS Genetics, 2021, 17(7): e1009649 (期刊论文) (本人标注:唯一通讯作者)

Gang Du^#; Zhiming Liu^#; Zihua Yu; Zhangpeng Zhuo; Yuedan Zhu; Juanyu Zhou; Yang Li; Haiyang Chen*; Taurine represses age-associated gut hyperplasia in Drosophila via counteracting endoplasmic reticulum stress, Aging Cell, 2021, 20(3): e13319 (期刊论文) (本人标注:唯一通讯作者)

Gang Du^#; Yicheng Qiao; Jiaqi Zhou; Zhangpeng Zhuo; Zhiming Liu; Yang li; Haiyang Chen*;Lipoic Acid Rejuvenates Aged Intestinal Stem Cells by Preventing Age-associated Endosome Reduction, EMBO Reports, 2020, 21(8): e49583 (期刊论文) (本人标注:唯一通讯作者)

Gang Du^#; Lishou Xiong^#; Xiaorong Li^#; Zhangpeng Zhuo; Xiaojun Zhuang; Zihua Yu; Lijian Wu; Danqing Xiao; Zhiming Liu; Minwen Jie; Xuehong Liu; Guanzheng Luo; Zheng Guo; Haiyang Chen*; Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair, Developmental Cell, 2020, 53(2): 169-184 (期刊论文) (本人标注:唯一通讯作者)

Haiyang Chen^#; Xiaobin Zheng^#; Danqing Xiao; Yixian Zheng*; Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence, Aging Cell, 2016, 15(3): 542-552 (期刊论文) (本人标注:第一作者)

Haiyang Chen^#; Xiaobin Zheng; Yixian Zheng*; Lamin-B in systemic inflammation, tissue homeostasis, and aging, Nucleus, 2015, 6(3): 183-186 (期刊论文) (本人标注:唯一第一作者)

Haiyang Chen^#; Xiaobin Zheng^#; Yixian Zheng*; Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia, Cell, 2014, 159(4): 829-843 (期刊论文) (本人标注:第一作者)

Haiyang Chen^#; Xin Chen; Yixian Zheng*; The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling, Cell Stem Cell, 2013, 13(1): 73-86 (期刊论文) (本人标注:唯一第一作者)

Haiyang Chen^#; Zhonghua Liu; Xun Huang*; Drosophila models of peroxisomal biogenesis disorder: Peroxins are required for spermatogenesis and very long chain fatty acid metabolism, Human Molecular Genetics, 2010, 19(3): 494-505 (期刊论文) (本人标注:唯一第一作者)

Haiyang Chen^#; Zhiguo Ma^#; Zhonghua Liu; Yuan Tian; Yanhui Xiang; Chao Wang; Matthew P. Scott; Xun Huang*; Case studies of ends-out gene targeting in Drosophila, Genesis, 2009, 47(5): 305-308 (期刊论文) (本人标注:第一作者)