中国动物学会动物行为学分会理事，中国神经学会离子通道与受体分会理事，中国生物信息学多组学与整合生物学专业委员会委员，中国人体健康科技促进会临床检验科学技术转化专业委员会委员，四川省高原医学专委会委员，四川省医疗卫生与健康促进会第一届糖尿病学与肥胖防治专委会委员。 

国家级青年人才项目，四川省“天府峨眉计划”创新团队首席，江苏省特聘教授（重点支持），四川省“天府峨眉计划”创新领军人才，青海省“昆仑英才·高端创新创业人才”项目柔性引进领军人才，江苏省杰青，江苏省三三三人才工程，江苏省双创人才和创业南京英才计划等。 以通讯作者（共通讯）在Nature, Cell, Nature communications, STTT-Cover Story, Advance science, MedComm, Mol. Biol. EvoL., Plos Biology, EMBO Reports, Pharmacological Research, Molecular Biomedicine, The FASEB Journal和The FEBS Journal等国际杂志发表多篇文章，授权专利7项。获教育部科学技术一等奖，江苏医学科技奖一等奖，中国海洋科学技术一等奖，江苏省第十五届青年科技奖暨“江苏省十大青年科技之星”、中国动物学会第七届青年科技奖等。

代表论文：

1.Hou G, Zhang S, Shen C, …., Cheng Deng*, He J*, Zhang Y*, Liu J*. Structural Basis of GABAB Receptor Activation during Evolution. Adv Sci (Weinh). 2025 Jul 12: e09440. doi: 10.1002/advs.202509440.*共同通讯作者

2.Shanshan Lai, Xianglin Kong, Jingwen Xue …, Cheng Deng*. A novel long-galanin peptide from non-mammalian vertebrates mitigates the inflammatory response in IBD models via the biased GALR2/β-arrestin2 pathway. Nature communications. online, *唯一通讯作者

3.Chang Zhang, Xue Wang, Chenxi Feng, … Yang He*, Peng Hu*, Qiu Sun*, Cheng Deng*. Nature communication. Avian GCGR is a Novel Perspective for Obesity Treatment by Continuously Facilitating Fat Utilization.online. doi:10.1038/s41467-025-66305-7. *共同通讯作者

4.Lu-Hua Gao, Hua Zheng, Qing Zhao,.. Yu Huang, Yi Chen, Cheng Deng*. GPR15 disparately regulates cigarette smoke exposure effect on Crohn's Disease and Ulcerative Colitis. Signal Transduct Target Ther. Cover Story. DOI: 10.1038/s41392-025-02384-8. *共同通讯作者

5.Chang Zhang1†,Xiangying Xiang1†, …Qiang Qiu4 Jürgen Brosius1, Cheng Deng*. Constitutively active glucagon receptor drives high blood glucose in birds. 2025. Nature. DOI: 10.1038/s41586-025-08811-8. *唯一通讯作者

6.Xin Wen, Pan Shang, Haidi Chen, …Pengju Zhang*, Fan Yang*, Cheng Deng*, Jin-Peng Sun*. Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4. 2025. Cell. DOI: 10.1016/j.cell.2024.12.001. *共同通讯作者

7.Huaping Zheng, Jingjing Yu, Luhua Gao , …Jürgen Brosius, Hu Zhang, Wei Yan†, Zhenhua Shao†, Fengming Luo†, Cheng Deng†. S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity. 2024. Nature communications. DOI: 10.1038/s41467-025-57124-x. *共同通讯作者

8.Siyuan Shen, Yue Deng, Chenglong Shen, Haidi Chen, …, Zhenhua Shao*, Cheng Deng*, Feng Ye*, Wei Yan*. Structural basis of neuropeptide Y signaling through Y1 and Y2 receptors. 2024. MedComm. DOI: 10.1002/mco2. *共同通讯作者

9.Ke Zhang，YanChen Guo，XiaoDong Wang，YingJie Zhu，BingXing Pan，Cheng Deng*，Ti-FeiYuan*2022. Lateral septum inputs to nucleus accumbens mediates stress induced suppression of natural reward Seeking. Pharmacological Research. DOI:10.1016/j.phrs.2022.106463. *共同通讯作者

10.Hongying Hao, Baolu Shi, Jiacheng Zhang, Ao Dai, Wenhao Li, Haidi Chen, … Juergen Brosius, Shanshan Lai* &Qinghua Shi* & Cheng Deng*. (2022)The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding. Molecular Biomedicine. Doi: 10.1186/s43556-022-00092-1. *通讯作者

11.Jingjing Song, Huaping zheng, …Jin Jin, Juergen Brosius, Cheng Deng* (2022) GPR15–C10ORF99 functional pairing initiates colonic Treg homing in amniotes. EMBO Reports. Doi: 10.15252/embr.202153246. *通讯作者

12.Chuan-Jun Shu#, Xuan Huang#, Hui-Hao Tang, Ding-Ding Mo, Jian-Wei Zhou*, Cheng Deng* (2021) Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2. Zoological Research. 2021, 42(2): 170-181 *通讯作者

13.Fang Liu#, Wei Yang#, Minghui Hu, Yong Zhang, Beicheng Sun, Hao Yang*, Juergen Brosius*, Cheng Deng*. (2021) Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its anti-tumor role. The FEBS Journal. DOI: 10.1111/FEBS.15763 *通讯作者

14.Shanshan Lai#, Ran Cheng#, Dan Gao, Ye-Guang Chen, Cheng Deng*. (2020) LGR5 constitutively activates NF-κB signaling to regulate the growth of intestinal crypts. The FASEB Journal. DOI: 10.1096/fj.202001329r *通讯作者

15.Huihao Tang#, Chuanjun Shu#, Haidi Chen#, Xiaojing Zhang, Zhuqing Zang, Cheng Deng* (2019). Constitutively active BRS3 is a genuinely orphan GPCR in placental mammals. Plos Biology. DOI: 10.1371/journal.pbio.3000175.*通讯作者

16.Lu Zhou#, Hang Sun#, Ran Cheng, Xiujun Fan, Shanshan Lai*, Cheng Deng*. (2019).ELABELA, as a potential diagnostic biomarker of pre-eclampsia, regulates Abnormally shallow placentation via APJ. American Journal of Physiology-Endocrinology and Metabolism. doi.org/10.1152/ajpendo.00383.2018.*通讯作者

17.Haidi Chen#, Li Chen#, Yune Wu, Hao Shen, Guang Yang, Cheng Deng* (2017).The exonization and functionalization of an Alu-J element in the protein coding region of glycoprotein hormone alpha gene represent a novel mechanism to the evolution of hemochorial placentation in primates. Molecular Biology and Evolution ,Volume 34,Issue 12,1 December 2017,Pages 3216–3231 *通讯作者

18.Cheng Deng, Haidi Chen, Na Yang, Yi Feng, Aaron J. W. Hsueh*. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. Journal of Biological Chemistry. DOI: 10.1074/jbc.M115.648238 *通讯作者

19.Cheng Deng, Chi-Hing Cheng, Hua Ye, Ximiao He, Liangbiao Chen. (2010) Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc. Natl. Acad. Sci. USA.107:21593–8.

20.Chen, Z., Cheng, C.H., Zhang, J., Cao, L., Chen, L., Zhou, L., Jin, Y., Ye, H., Deng, C., Dai, Z.,et al. (2008). Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fishes. Proc. Natl. Acad. Sci. USA. 105:12944-12949.