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首页 > 学科导师 > 疾病分子与转化医学 > 博导
邓成 疾病分子与转化医学
1982-07 | 博导
  • 13405855560

  • dengcheng2014@126.com

    • cc1.GPCR的分子进化与生理功能研究2.致病基因功能多肽药物3.GPCR靶点开发
  •     邓成,男,四川乐山人。教授/博导,国家级青年人才项目入选者。中国动物学会动物行为学分会理事,中国神经学会离子通道与受体分会理事,江苏省动物学会青年委员会主任、副秘书长和常务理事,江苏省细胞与发育生物学会理事。入选国家级青年人才项目,江苏省特聘教授(重点支持),四川省“天府峨眉计划”创新领军人才,江苏省杰青,江苏省双创人才和创业南京英才计划等。以通讯作者在Mol. Biol. EvoL., Plos Biology, EMBO Reports, Pharmacological Research,Molecular Biomedicine, The FASEB Journal和The FEBS Journal等国际杂志发表多篇文章,授权专利3项, 获得教育部科学技术一等奖,江苏医学科技奖一等奖,中国海洋科学技术一等奖,江苏省第十五届青年科技奖暨“江苏省十大青年科技之星”、中国动物学会第七届青年科技奖等。

  •     中国动物学会动物行为学分会理事,中国神经学学会离子通道与受体分会理事,江苏省动物学会青年委员会主任和副秘书长及常务理事,江苏省细胞与发育生物学会理事与北美华人生物医药协会(CABS)会员;国际期刊Asian Journal of Pharmaceutical Sciences (AJPS),Zoological Research, STEMedicine编委。

  • 主持的科研项目:

    1. 国家重点研发重点专项子课题,2022-2026;

    2. 国家自然科学基金面上项目,2019-2022;

    3. “创业南京”英才计划,2018-2020;

    4. 国家重点研发计划“蓝色粮仓科技创新” 重点专项第二子课题,2018-2020;

    5. 江苏省创新创业人才项目,2017-2019;

    6. 江苏省杰出青年基金,2017-2019;

    7. 江苏省特聘教授(重点支持),2016-2018;

    8. 国家自然科学基金青年项目,2015-2017;

    9. 江苏省教育厅自然科学重大项目;

    10. 江苏省 “六大人才高峰”高层次人才基金;

    11. 教育部留学回国人员科研启动基金。

    获奖与荣誉称号:

    1. 四川省“天府峨眉计划”创新领军人才项目-2022年

    2. 江苏医学科技奖一等奖(排第三)-2021年;

    3. 高等学校科学研究优秀成果奖(科学技术)-自然科学奖一等奖(排第三)-2020年;

    4. 中国海洋科学技术奖一等奖(排第七)-2019年;

    5. “创业南京”英才计划-2018年;

    6. 江苏省创新创业人才-2017年;

    7. 中国动物学会第七届青年科技奖-2017年;

    8. 江苏省第十五届青年科技奖暨“十大青年科技之星” -2016年;

    9. 江苏省第十三批“六大人才高峰”高层次人才-2016年;

    10. 江苏省杰出青年基金获得者-2016年;

    11. 国家级青年人才项目入选者-2016年;

    12. 江苏省特聘教授称号(重点支持)-2015年;

    论文发表

    1. Siyuan Shen, Yue Deng, Chenglong Shen, Haidi Chen,Lin Cheng, Chao Wu, Chang Zhao,Zhiqian Yang, Hanlin Hou,Kexin Wang, Zhenhua Shao∗, Cheng Deng∗, Feng Ye∗ ,Wei Yan1∗.Structural basis of neuropeptide Y signaling through Y1 and Y2 receptors.Medcomm.DOI: 10.1002/mco2.565. *通讯作者

    2. Ke Zhang,YanChen Guo,XiaoDong Wang,YingJie Zhu,BingXing Pan,Cheng Deng*,Ti-FeiYuan*2022. Lateral septum inputs to nucleus accumbens mediates stress induced suppression of natural reward Seeking[J]. Pharmacological Research. DOI:10.1016/j.phrs.2022.106463. *通讯作者

    3. Hongying Hao, Baolu Shi, Jiacheng Zhang, Ao Dai, Wenhao Li, Haidi Chen, … Juergen Brosius, Shanshan Lai* &Qinghua Shi* & Cheng Deng*.(2022)The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding. Molecular Biomedicine. Doi: 10.1186/s43556-022-00092-1. *通讯作者

    4. Haidi Chen, Jingwen Xue, Zhenghou Zhang, Geyu Zhang, Xinyuan Xu, He Li, Ruxue Zhang, Najeeb Ullah, Lvxing Chen, Zhuqing Zang, Shanshan Lai, Ximiao He, Wei Li, Miao Guan*, Jingyi Li*, Liangbiao Chen*, Cheng Deng*. (2022)High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote. Scientific Reports. Doi: 10.1038/s41598-022-06250-3. *通讯作者

    5. Jingjing Song, Huaping zheng, …Jin Jin, Juergen Brosius, Cheng Deng* (2021) GPR15–C10ORF99 functional pairing initiates colonic Treg homing in amniotes. EMBO Reports. Doi: 10.15252/embr.202153246. *通讯作者

    6. Changping Yu,Runjie Diao,Ranjha Khan,Cheng Deng,Hui Ma,Zhijie Chang,Xiaohua Jiang  and Qinghua Shi(2021),The Dispensable Roles of X-Linked Ubl4a and Its Autosomal Counterpart Ubl4b in Spermatogenesis Represent a New Evolutionary Type of X-Derived Retrogenes. Frontiers in Genetics. Doi: 10.3389/fgene.2021.689902

    7. Chuan-Jun Shu#, Xuan Huang#, Hui-Hao Tang, Ding-Ding Mo, Jian-Wei Zhou*, Cheng Deng* (2021) Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2. Zoological Research. 2021, 42(2): 170-181 *通讯作者

    8. Fang Liu#, Wei Yang#, Minghui Hu, Yong Zhang, Beicheng Sun, Hao Yang*, Juergen Brosius*, Cheng Deng*.  (2021) Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its anti-tumor role. The FEBS Journal.  DOI: 10.1111/FEBS.15763 *通讯作者

    9. Shanshan Lai#, Ran Cheng#, Dan Gao, Ye-Guang Chen, Cheng Deng*. (2020) LGR5 constitutively activates NF-κB signaling to regulate the growth of intestinal crypts. The FASEB Journal. DOI: 10.1096/fj.202001329r *通讯作者 

    10. Na Yang#, Haidi Chen#, Minghui Hu#, Geyu Zhang#, Amanullah, Cheng Deng*. (2020) Evolution of a splice variant that acts as an endogenous antagonist of the original INSL3 in primates. Gene. DOI: 10.1016/j.gene.2020.144861 *通讯作者 

    11. Lina Zhang, Jingjing Song, Zhuqing Zang, Huihao Tang, Wei Li, Shanshan Lai*, Cheng Deng*. Adaptive evolution of GPR39 in diverse directions in vertebrates, General and Comparative Endocrinology, 2020, 113610, ISSN 0016-6480, *通讯作者 

    12. C Shu, X Huang, J Brosius, C Deng*. Exploring Potential Super Infection in SARS-CoV2 by Genome-Wide Analysis and Receptor–Ligand Docking. Preprints *通讯作者

    13. C Shu, X Huang, T Huang, L Chen, B Yao, J Zhou, C Deng*.Potential inhibitors for targeting Mpro and Spike of SARS-CoV-2 based on sequence and structural pharmacology analysis. 2020. STEMedicine 1 (2), e41-e41. *通讯作者  

    14. Huihao Tang#, Chuanjun Shu#, Haidi Chen#, Xiaojing Zhang, Zhuqing Zang, Cheng Deng* (2019). Constitutively active BRS3 is a genuinely orphan GPCR in placental mammals. Plos Biology. DOI: 10.1371/journal.pbio.3000175.*通讯作者

    15. Lu Zhou#, Hang Sun#, Ran Cheng, Xiujun Fan, Shanshan Lai*, Cheng Deng*. (2019).ELABELA, as a potential diagnostic biomarker of pre-eclampsia, regulates Abnormally shallow placentation via APJ. American Journal of  Physiology-Endocrinology and Metabolism. doi.org/10.1152/ajpendo.00383.2018.*通讯作者

    16. Haidi Chen#, Li Chen#, Yune Wu, Hao Shen, Guang Yang, Cheng Deng* (2017).The exonization and functionalization of an Alu-J element in the protein coding region of glycoprotein hormone alpha gene represent a novel mechanism to the evolution of hemochorial placentation in primates. Molecular Biology and Evolution ,Volume 34,Issue 12,1 December 2017,Pages 3216–3231 *通讯作者

    17. Cheng Deng*, Haidi Chen, Na Yang, Yi Feng, Aaron J. W. Hsueh*. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. Journal of Biological Chemistry. DOI: 10.1074/jbc.M115.648238 *通讯作者

    18. Cheng Deng* & Aaron J. W. Hsueh. (2013) Evolution of a potential hormone antagonist following gene splicing during primate evolution. Plos One. DOI: 10.1371/journal.pone.0064610.*通讯作者

    19. Cheng Deng*, Ximiao He, Aaron J. W. Hsueh*. (2013) A single-nucleotide polymorphism of human Neuropeptide S gene originated from Europe shows decreased bioactivity. Plos One. DOI: 10.1371/journal.pone.0083009. *通讯作者 

    20. Cheng Deng, Pradeep Reddy, Yuan Cheng, Ching-Wei Luo, Chih-Lun Hsiao, and Aaron J. W. Hsueh. (2013) Multi-functional norrin is a ligand for the LGR4 receptor. Journal of Cell Science. DOI: 10.1242/jcs.123471.

    21. Cheng Deng, Chi-Hing Cheng, Hua Ye, Ximiao He, Liangbiao Chen. (2010) Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc. Natl. Acad. Sci. USA.107:21593–8.

    22. Yang Na1, Peng Changlian1, Cheng Deng, Huang Qiao, Xu Guanghui, Gao Fei, Chen Liangbiao. (2013). The over-expression of calmodulin from Antarcticnotothenioidfish increases cold tolerance in tobacco. Gene. doi: 10.1016/j.gene.2013.03.048.1共同第一作者

    23. Chen, Z., Cheng, C.H., Zhang, J., Cao, L., Chen, L., Zhou, L., Jin, Y., Ye, H., Deng, C., Dai, Z.,et al. (2008). Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fishes. Proc. Natl. Acad. Sci. USA. 105:12944-12949.

    24. Zhang J, Deng C, Wang J. and Chen Liangbiao. (2009). Identification of a two-domain antifreeze protein gene in Antarctic eelpout Lycodichthys dearborni. Polar Biol. DOI 10.1007/s00300-008-0499-8.

    25. Chen L, Cao L, Zhou L, Jing Y, Chen Z, Deng C, Shen Y, (2007). Trehalose as a good candidate for enriching full-length cDNAs in cDNA library construction. J. Biotech. 127: 402-407.

    科学报道

    1. University of Illinois at Urbana-Champaign. "Antifreeze proteins: How one gene becomes two (with different functions)." Science Daily,

    2. Evolutionary Significance of Whole-Genome Duplication, Polyploidy and Genome Evolution. Springer, 2012.

    3. Ice as an evolutionary driver, Adaptation and Evolution in Marine Environments. Page 60, Springer, 2012.

    4. Antifreeze proteins in fish, The New Answers Book 4: Over 25 Questions on Creation/Evolution and the Bible, Page 297-8, New Leaf Publishing Group, Aug, 2013.

    5. Norrin activation of LGR4. Stanford technology Licensing.

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