神经外科博士、博士后,副教授,硕士生导师;
2014年毕业于四川大学华西临床医学院临床医学8年制;
主要研究方向:脑血管病相关临床与基础研究,包括:
(1) 脑出血后血管再生、自噬、氧化应激等相关机制,
(2) 出血性脑卒中(脑出血、动脉瘤等)预后相关生物标志物等;
(3) 脑血管病大数据研究;
目前以第一作者和通讯作者(含共同)在Lancet, J stroke, Int J stroke, Neurology等期刊发表SCI论文30篇,单篇最高影响因子168.9,获得国家级等课题共4项,指南执笔1项。
中国研究型医院学会神经再生与修复专业委员会委员
Ø 近年学术成果
以第一作者和通讯作者(含共同)在Lancet, J stroke, Int J stroke, Neurology等期刊发表SCI论文30篇,单篇最高影响因子168.9,部分罗列如下:
1. Ma L, Hu X, Song L, et al. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial. Lancet. 2023;402(10395):27-40. <标志性成果>,共同第一作者
2. Fang M, Xia F, Wang J, et al. The NLRP3 inhibitor, OLT1177 attenuates brain injury in experimental intracerebral hemorrhage. Int Immunopharmacol. 2024;131:111869. 通讯作者
3. Hu X, Fang M, Tao C, et al. New era for intracerebral haemorrhage management: Lessons from INTERACT3. Clin Transl Med. 2023;13(10):e1419. 第一作者
4. Fang M, Wang J, Wang Z, et al. Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke. Front Neurol. 2023;14:1097183. 通讯作者
5. Chen Y, Fang M, Wu P, et al. Seizure prophylaxis following aneurysmal subarachnoid haemorrhage (SPSAH): study protocol for a multicentre randomised placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute subarachnoid haemorrhage. BMJ Open. 2022;12(5):e057917. 通讯作者
6. Wang T, Li J, Hu X, Zheng S. Rapid Disappearance of Acute Unilateral Epidural Hematoma Due to Compression of Contralateral Subdural Hematoma. Neurology. 2021;97(22):1031-2. 通讯作者
7. Song L, Hu X, Ma L, et al. INTEnsive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3): study protocol for a pragmatic stepped-wedge cluster-randomized controlled trial. Trials. 2021;22(1):943. 共同第一作者
8. Li Y, Wen D, Cui W, et al. The Prognostic Value of the Acute Phase Systemic Immune-Inflammation Index in Patients With Intracerebral Hemorrhage. Front Neurol. 2021;12:628557. 通讯作者
9. Chen Y, Xia F, Li Y, et al. Changes in Characteristics, Treatment and Outcome in Patients with Hemorrhagic Stroke During COVID-19. J Stroke Cerebrovasc Dis. 2021;30(3):105536. 通讯作者
10. Chen Y, Xia F, Cai C, et al. Duration and choices of prophylactic anticonvulsants in subarachnoid hemorrhage: a systematic review and meta-analysis. Neurosurg Rev. 2021;44(5):2459-67. 通讯作者
11. Xia F, Yu X, Li Y, et al. Geographic Variations of Stroke Incidence in Chinese Communities: An 18-Year Prospective Cohort Study from 1997 to 2015. J Stroke. 2020;22(3):345-56. 通讯作者
12. Hu X, Xie Z, Zan X, et al. Role of Apolipoprotein E Genotypes in Aneurysmal Subarachnoid Hemorrhage: Susceptibility, Complications, and Prognosis. World Neurosurg. 2018;118:e666-e76. 第一作者
13. Tao C, Hu X, Wang J, et al. Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage. Biomark Med. 2017;11(1):33-42. 共同第一作者
14. Tao C, Hu X, Li H, et al. White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic Strategies. Front Hum Neurosci. 2017;11:422. 共同第一作者
15. Hu X, Zan X, Xie Z, et al. Association Between Plasminogen Activator Inhibitor-1 Genetic Polymorphisms and Stroke Susceptibility. Mol Neurobiol. 2017;54(1):328-41. 第一作者
16. Wang Q, Hu X, Wang Y, et al. A huge intramedullary solitary fibrous tumor. Neurology. 2016;87(20):2171-2. 共同第一作者
17. Hu X, Tao C, Gan Q, et al. Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets. Oxid Med Cell Longev. 2016;2016:3215391. 第一作者
18. Hu X, Fang Y, Hui X, et al. Radiotherapy for diffuse brainstem glioma in children and young adults. Cochrane Database Syst Rev. 2016(6):Cd010439. 第一作者
Ø 课题
1. 国家自然科学基金青年基金1项;
2. 四川省科技厅重点研发项目1项;
3. 四川省卫健委科技项目1项;
4. 四川大学华西医院临床孵化项目1项;
Ø 获奖
华夏医学科技奖二等奖
Ø 指南、共识编写
指南执笔:《出凝血功能障碍相关性脑出血中国多学科诊治指南》
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