博士，副教授，四川大学华西医院科技部副部长。2016年留院工作于四川大学华西医院老年医学中心/干部医疗科，主要参与老年谵妄的评估与多学科干预、老年急性照护病房及老年功能促进的多学科团队建设工作等。2017年至2021在美国University of Texas at Austin从事博士后研究。候选人聚焦“老年认知障碍及失能防控关键技术体系”,遵循“新技术-新靶点-新体系”研究范式，开展系列基础与临床转化研究。主持 2 项国家自然科学基金、2 项国家科技创新 2030 重大/重点项目子课题等国家/省部级项目共9项(总经费 超400万);在各级学术刊物发表论文 60 余篇（SCI 论文 26 篇），以第一和通讯作者（含共同）在 JAMA Intern Med(中科院 1 区 TOP, IF=22.5)、Cell Metab (中科院 1 区 TOP, IF= 27.7，封面)、Nature Aging(中科院 1 区 TOP, IF=17)等医学权威期刊发表论文20 篇。受邀参编国内外规划教材/专著 8 部; 授权发明专利和软著 7 项，成果转化1项;担任中华医学会医学科学研究管理学分会青委、中国医学装备协会医疗器械创新与应用分会常委、中国睡眠研究会青委、中国康复医学会慢病康复专委会委员、Precision Clinical Medicine 青委、International Journal of Nursing Sciences 编委等多项学术任职；2023 年入选四川省“天府青城计划”青年科技菁英人才；2024 年获华夏医学科技奖二等奖（排名 3）。
Dr.Wang is a PhD, associate Professor, and the deputy director of the Science and Technology Department at West China Hospital of Sichuan University. She joined West China Hospital in 2016 and has since been engaged primarily in the assessment and multidisciplinary intervention for delirium in elderly patients, as well as the establishment of multidisciplinary teams within acute care units for older adults aimed at promoting their functional capabilities.
From 2017 to 2021, Dr. Wang conducted postdoctoral research at the University of Texas at Austin in the United States. Her research focuses on developing key technological systems to prevent cognitive impairment and disability among older adults, adhering to a research paradigm characterized by "new technologies - new targets - new systems." This work encompasses a series of basic science investigations and clinical translational studies.
She has led nine national/provincial/ministerial-level projects with total funding exceeding 4 million yuan; this includes two projects funded by the National Natural Science Foundation and two sub-projects under major initiatives outlined in China's National Science and Technology Innovation Plan (2030). Dr. Wang has published over 60 academic articles across various journals, including 26 papers indexed by SCI. Notably, She has contributed as either first or corresponding author to twenty articles published in prestigious medical journals such as JAMA Internal Medicine (IF=22.5), Cell Metabolism (IF=27.7; cover article), and Nature Aging (IF=17).
Additionally, She has been invited to co-edit eight domestic and international planning textbooks/monographs, holds seven patents along with software copyrights, achieved one technology transfer, serves as a young committee member of the Medical Research Management Branch of the Chinese Medical Association, an executive committee member of the Medical Equipment Innovation and Application Branch of the China Medical Equipment Association, a young committee member of the Sleep Research Society of China.
• 2017年至今，中国睡眠研究会青年工作委员会第二届青年委员
• 2018年至今，担任精准临床医学杂志 (ISSN 2096-5303) 青年编委
• 2018年至今，担任国际高水平期刊Nursing Research (ISSN 0029-6562) 同行评审专家
• 2019年至今，四川大学华西医学院华西医院副教授、副护士长
• 2020年，荣获“四川省干部保健青年骨干
• 2021年至今，中国护理学会高级会员
• 2021年至今，国家老年病临床研究中心专家
• 2021年1月至今，国家老年疾病临床医学研究中心（四川大学华西医院）专家库专家”
• 2022年至今，中国康复医学会慢病康复专业委员会第一届委员会委员
• 2018年至2022年，成都护理学会第11届理事会管理专业委员会秘书
• 2022年至今，医学科技转移管理中级证书
• Youth Member of the Second Youth Committee of the Chinese Sleep Research Society,2017-present
• Youth Editorial Board Member of Precision Clinical Medicine (ISSN 2096-5303),2018-present
• Peer Reviewer for Nursing Research (ISSN 0029-6562), an International high-level magazine,2018-present
• Associate Professor and Deputy Head Nurse at the West China School of Medicine, West China Hospital, Sichuan University,2019-present
• Awarded the "Sichuan Province Cadre Health Youth Backbone",2020
• Senior Member of the Chinese Nursing Association,2021-present
• Expert at the National Geriatric Clinical Research Center,2021-present
• Expert in the Expert Database of the National Clinical Research Center for Geriatric Diseases (West China Hospital, Sichuan University)，2021-present
• Member of the First Committee of the Chronic Disease Rehabilitation Professional Committee of the Chinese Association of Rehabilitation Medicine,2022-present
• Secretary of the 11th Board of Directors, Management Professional Committee, Chengdu Nursing Association,2018-2022
• Intermediate Certificate in Medical Science and Technology Transfer Management,2022-present
国家自然科学基金青年项目、国家科技部重点研发计划子课题负责人、四川省科技厅项目、四川省卫生计生委普及应用项目、四川大学华西医院博士后基金项目等。以主研身份参与国家自然科学基金面上项目、四川省科技计划重点研发项目、国家科技部科技计划项目、成都市人社局科研项目等。部分包括：
1) “睡眠呼吸障碍对术后谵妄和认知障碍的影响及机制研究”
项目编号：81800092，国家自然科学基金项目，经费：21万元，执行时间：2019年1月-2021年12月
2) “经颅交变电流刺激在中老年睡眠障碍患者中的应用及机制研究”
项目编号：82270106，国家自然科学基金项目，经费：52万元，执行时间：2023年1月-2026年12月
3) “靶向和验证新型经颅交变电流刺激（tACS）在慢性失眠症治疗中的有效性”
项目编号：20212D0201905-3，睡眠障碍发病机制与干预技术研究，国家科技部脑科学与类脑研究重大专项领域资助项目，经费：120万元，执行时间：2021年12月-2025年12月
4) “特殊监测技术和即时干预技术对老年患者围术期结局及长期预后的影响”
项目编号：2018YFC2001802-1，国家科技部资助项目，经费：40万元，执行时间：2018年12月-2022年12月
5) “基于互动游戏系统的老年人认知评估与决策支持研究”
项目编号：2022YFH0074，国际科技创新合作项目，四川省科技厅资助，经费：30万元，执行时间：2022年1月-2023年12月
6) “阻塞性睡眠呼吸暂停对接受腹部手术老年患者围术期神经认知功能的影响及相关机制研究”
项目编号：20PJ022，四川省卫健委资助项目，经费：2万元，执行时间：2020年1月-2021年12月
7) “阻塞性睡眠呼吸暂停对接受腹部手术老年患者围术期神经认知功能的影响及相关机制研究”
项目编号：2020H1X1BH020，四川大学华西医院博士后基金项目，经费：15万元，执行时间：2020年9月-2022年8月
8) “基于大型综合医院门急诊信息的四川地区空气污染引起的呼吸系统疾病风险与管理研究”
项目编号：2018ZR0007，四川省科技厅资助项目，经费：30万元，执行时间：2018年1月-2019年12月
9) “住院老年患者睡眠障碍的筛查及循证管理模式的构建”
项目编号：17PJ281，四川省卫健委普及应用项目，经费：0.5万元，执行时间：2017年-2019年
10) “高层次复合型医学人才培养模式改革与探索——以四川大学临床医学院为例”
项目编号：GSSCU2023098，四川大学研究生教育教学改革研究项目，经费：0.6万元，执行时间：2023年12月-2025年12月
发表文章：
1. Yanyan Wang, Jirong Yue, Dongmei Xie, Carter P, Li Q L, Gartaganis S L, Chen J & Sharon K. Inouye. Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and Function in Older Adults: A Randomized Clinical Trial. JAMA Internal Medicine, 2020, 180(1): 17-25.
Cited by 2 guidelines:
1) Melloul, E, Hübner, M, Scott, M et al. Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations. World J Surg, 2016.
2) Oodit, R, Biccard, BM, Panieri, E et al. Guidelines for Perioperative Care in Elective Abdominal and Pelvic Surgery at Primary and Secondary Hospitals in Low–Middle-Income Countries (LMIC’s): Enhanced Recovery After Surgery (ERAS) Society Recommendation. World J Surg, 2022.
2. He Q1, Ji L1, Wang Y1, Zhang Y1, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T. Acetate enables metabolic fitness and cognitive performance during sleep disruption. Cell Metabolism. 2024 Aug 12:S1550-4131(24)00290-0.
3. Xinrong Zuo1, Rui Zhao1, Minming Wu1, Yanyan Wang1, Shisheng Wang, Kuo Tang, Yang Wang, Jie Chen......Tao Li*. Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target. Nature Aging, 2024 Dec, Accepted
4. Shi Y, Tian X, Li T, Hu Y, Xie Y, Li H, Li Y, Jiang N, Tang X, Wang Y*. The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study. Sleep Med. 2024 Dec 9;126:185-193. doi: 10.1016/j.sleep.2024.12.011.
5. Xie, Y., Xia, X., Tian, X. et al. The association between cognitive impairment and oral health or oral hygiene behaviors among multiethnic older adults in Western China: a cross-sectional multicenter study. BMC Public Health (2024). https://doi. 10.1186/s12889-024-21158-5
6. Wu W, Pu L, Hu X, Chen Q, Wang G, Wang Y*. Moderate-to-high risk of obstructive sleep apnea with excessive daytime sleepiness is associated with postoperative neurocognitive disorders: a prospective one-year follow-up cohort study. Frontiers in neuroscience, 2023, 17.
7. Li Y, Xia X, Wu W, Tian X, Hu Y, Dong B, Wang Y*. The Mediating Effects of Nutritional Status on the Relationship between Number of Residual Teeth and Cognitive Function among Older Adults: A Cross-Sectional Multicenter Study. Nutrients, 2023, 15(14), 3089.
8. Ye, W., Han, K., Xie, M., Li, S., Chen, G., Wang, Y.,* & Li, T.* (2024). Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets. Chinese medical journal, 137(8), 936–948.
9. Fan M, Tang L, Song H, Wang Y*. Foramen ovale thrombus found during extracorporeal left ventricular assist device implantation. Asian Journal of Surgery, 2024, 1015-9584.
10. Lan X, Fan M, Peng W, Wang Y*. Adductor canal block versus femoral canal block for total knee arthroplasty: A meta-analysis of randomized controlled trials. Asian Journal of Surgery, 2023,46(11): 5094-5095.
11. Wang Y, Cheng C, Moelter S, et al. One Year of Continuous Positive Airway Pressure Adherence Improves Cognition in Older Adults with Mild Apnea and Mild Cognitive Impairment. Nursing Research, 2020, 69(2): 157-164.
12. Richards KC, Wang YY, Jun J, Ye L. A Systematic Review of Sleep Measurement in Critically Ill Patients. Frontiers in Neurology. 2020, 11: 542529.
13. Richards K, Morrison J, Wang YY, et al. Nighttime Agitation and Restless Legs Syndrome in Persons with Alzheimer's Disease: Study Protocol for a Double-Blind, Placebo-Controlled, Randomized Trial (NightRest). Research In Gerontological Nursing, 2020, 13(6): 280-288.
14. Huang Kai-Sen, Wang Yan-Yan, Deng Xiao-Jan, et al. Acute changes in hs-cTnI in an exercise test setting: a clinical tool for risk stratification in exercise-based cardiac rehabilitation. International Journal of Clinical and Experimental Medicine, 2020, 13(3): 1767-1775.
15. Wenting Li, Lun Tan, Zhixiong Zhang…Yanyan Wang*. The X-ray structure of tubulysin analogue TGL in complex with tubulin and three possible routes for the development of next-generation tubulysin analogues. Biochemical and Biophysical Research Communications. 2021, 565:29-35.
16. Lei JH, Ma LL, Xian JH… Wang YY*, Wang YX*. Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design. RSC advances, 2021, 11, 18938-18944.
17. Zhixiong Zhang, Guan Wang, Yuyan L…Yanyan Wang *, Jinliang Yang*. Recent progress in DNA methyltransferase inhibitors as anticancer agents. Frontiers In Pharmacology, 2022, 13: 1072651.
18. Richards KC, Allen RP, Morrison J…Wang Y, et al. Nighttime Agitation in Persons with Dementia as a Manifestation of Restless Legs Syndrome. Journal of the American Medical Directors Association, 2021, 22(7): 1410-1414.
19. Kai-Sen Huang, Debarati…Yan-Yan Wang, et al. Disability-Adjusted Life Years (DALYs) Due to Ischemic Heart Disease (IHD) Associated with Natural Disasters: A Worldwide Population-Based Ecological Study. Global Heart, 2021, 16(1): 30.
20. Richards KC, Gooneratne N, Dicicco B, Hanlon A, Moelter S, Onen F, Wang Y, et al. CPAP Adherence May Slow 1-Year Cognitive Decline in Older Adults with Mild Cognitive Impairment and Apnea. Journal of the American Geriatrics Society, 2019, 67(3):558-564.
21. Zhao Y, Xia X, Xie D, Liao Y, Wang Y, et al. Geriatric Nutritional Risk Index can predict postoperative delirium and hospital length of stay in elderly patients undergoing non-cardiac surgery. Geriatrics & Gerontology International, 2020, 20(8): 759-764.
22. Zhao Y, Ge N, Xie D, Gao L, Wang Y, et al. The geriatric nutrition risk index versus the mini-nutritional assessment short form in predicting postoperative delirium and hospital length of stay among older non-cardiac surgical patients: a prospective cohort study. BMC Geriatrics, 2020; 20(1): 107.
23. Wang YY, Liao YL, Gao LL, et al. [Localization Establishment of an Interdisciplinary Intervention Model to Prevent Post-Operative Delirium in Older Patients Based on 'Hospital Elder Life Program']. Hu Li Za Zhi, 2017, 64(3): 33-42.
24. Pretorius K, Cengiz A, Geshell L…Wang Y, et al. What Bed Size Does a Patient Need?: The Relationship Between Body Mass Index and Space Required to Turn in Bed. Nursing Research, 2018, 67(4): 273-274.
25. Rong Ren, Naima Covassin…Yanyan Wang, et al. Objective but Not Subjective Short Sleep Duration Is Associated With Hypertension in Obstructive Sleep Apnea. Hypertension, 2018, 72:610-617.
26. Liao Y, Flaherty JH, Yue J, Wang Y, et al. The incidence of delirium after cardiac surgery in the elderly: protocol for a systematic review and meta-analysis. BMJ Open, 2017, 7(3): e014726.
27. Zhixiong Zhang, Chengdi Wang, Lingling Ma…Yanyan Wang, et al. Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design. Biochemical And Biophysical Research Communications. 2019, 511(2): 381-386.
28. Dongmei Xie, Yulin Liao… Yanyan Wang, Chuanyao Deng, Ling Chen. Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis. BMJ open, 2018, 8(3):1-10.
29. Tingting Liu, Dongmei Wu, Jing Wang … Yanyan Wang. Validating the information-motivation-behavioral skills model of diabetes self-management among Chinese adults with type 2 diabetes: A longitudinal study, BMJ open, 2018, 8(10).
30. Cheng J, Wu Y, Wang Y, et al. Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design. Biochemical And Biophysical Research Communications, 2018, 495(1): 185-188.
31. Wang Y, Pu L, Li Z, et al. Hypoxia-Inducible Factor-1α Gene Expression and Apoptosis in Ischemia-Reperfusion Injury: A Rat Model of Early-Stage Pressure Ulcer. Nursing Research, 2016, 65(1): 35-46.
32. Jiang LP, Tu Q, Wang Y, et al. Ischemia-reperfusion injury-induced histological changes affecting early stage pressure ulcer development in a rat model. Ostomy Wound Manage, 2011, 57(2): 55-60.
ChChinese (Indexed in Medline or Chinese Science Citation Database):
33. Yuexia Hu, Xin Xia…Yanyan Wang*. Analysis of the relationship of COVID-19 vaccination and critical cases of inpatients infected with Omicron variants. Chinese Journal of Evidence-Based Medicine, 2024
34. Yi Zheng, Xiankun Sun…Yanyan Wang*. Research progress on the application of regional citrate anticoagulation in continuous renal replacement therapy patients with hyperlactatemia. Chinese Journal of Nephrology, 2024
35. Chunlin Du, Zheng Tang…Yanyan Wang*. Effectiveness analysis of chronic disease continuous health management services based on a patient satisfaction survey. West China Medical Journal. 2023, 38(04):487-493.
36. Zheng Tang, Wei Li… Yanyan Wang*, Li Ma*. Construction and practice of information platform for Internet+NCDs continuous health management mode. China Digital Medicine. 2023, 18(3):20-26.
37. Shiqi Chen, Yanyan Wang, et al. Particulate Matters and Non-accidental Emergency Visits in West China Hospital: a Time-Series Study. Journal of Sichuan University (Medical Sciences). 2019, 50 (1):71-76.
38. Yanyan Wang, Chuanyao Deng, et al. Development and validation of the China Leisure Time Physical Activity Questionnaire in the elderly. Practical Geriatrics. 2019, 33(3): 229-233.
39. Chuanyao Deng, Yanyan Wang, Dongmei Xie, et al. Effects of Hospital Elder Life Program-based interdisciplinary intervention on prevention of postoperative delirium in the elderly. Practical Geriatrics. 2019, 33(1): 12-15.
40. Ling Chen, Jirong Yue, Langli Gao, Yanyan Wang*. Preliminary validation and feature word extraction of the electronic medical record evaluation delirium scale. Journal of Sichuan University (Medical Sciences). 2019,50(1): 136-138.
41. Yulin Liao, Dongmei Xie, Jirong Yue, Yanyan Wang, et al. Analysis of the incidence and risk factors of postoperative delirium in the elderly after non-cardiac surgery. Practical Geriatrics. 2019, 33(2): 115-120.
42. Xiuying Hu, Chunlan Bai…Yanyan Wang, et al. Investigation on the full range of health care model for older people under the rapid aging process. Chinese Nursing Management. 2018, 18(5): 590-596.
43. Yunxia Zhang, Xiaoyan Chen, Yanyan Wang, et al. Reliability and validity analysis of the Adult Disability Assessment Tool Scale. Journal of Sichuan University (Medical Sciences). 2018, 49(5): 789-792.
44. MeiR Fu, Yali Tian, Xianqiong Feng…Yanyan Wang, et al. Application fields and development directions of precision nursing. Chinese Journal of Nursing. 2017, 52(10): 1273-1275.
45. Yanyan Wang, Yulin Liao, Jirong Yue. Research on the mechanism of delirium based on related serum biomarkers of the delirium. JOURNAL OF BIOMEDICAL ENGINEERING. 2017 (3): 465-470.
46. Yanyan Wang, Jirong Yue, Xiuying Hu. Research progress of post-operative delirium on elderly patients. Chinese Journal of Practical Nursing. 2015, 31(27): 2097-2100.
47. Zhi Li, Yanyan Wang, Xiuying Hu. The progress of information management in evidence-based nursing practice: a literature review. Chinese Nursing Management, 2015, 15(10): 1268-1270.
48. Yanyan Wang, Ruili Wang. Practice and thinking of “surgical nursing” bilingual teaching. Chinese Nursing Research, 2013, 27(10C): 3440-3442.
49. Yanyan Wang, Jia Chen, Liping Jiang. Expression and role of hypoxia inducible factor-1 α and matrix metalloproteinase-9 during early development of pressure ulcer. Journal of Nursing Science. 2012, 27(5): 3-6.
50. Yanyan Wang, Liping Jiang, et al. Investigate the expression and role of apoptosis-related proteins Bcl-2/Bax in early stage pressure ulcer. Chinese Journal of Burns. 2011, 27 (3):197-199.
51. Yanyan Wang, Chunyu Zhang, et al. The role of oxidative stress and apoptosis in the progress of early stage pressure ulcer. Chinese Journal of Nursing. 2011, 46(5): 523-525.
52. Yanyan Wang, Haiqin Sun, et al. Establishing and Evaluation of an Animal Model of Early Stage Pressure Ulcer, Journal of Nursing Science, 2010, 25(14): 1-5.
53. Yanyan Wang, Liping Jiang, et al. Biomechanical, Cyclic and Metabolic Progress of Pressure Ulcer. Journal of Nursing Science, 2010, 25(8):93-96.
54. Liping Jiang, Yanyan Wang, Chunyu Zhang, Yan Sun. Activity of adenosine triphosphatase and the expression of ryanodine receptor 1 mRNA in local tissue of pressure ulcer at early stage in gracilis of rats. Chinese Journal of Burns. 2011, 27(03):178-182.
55. En Zhang, Qian Tu, Yanyan Wang, et al. Apoptosis mediated by Fas/FasL in Ⅲ-stage pressure ulcers and its role in ulcer healing. Chinese Journal of Pathophysiology, 2010, 26(5): 1006-1008.
参编专著：
《居家社区养老护理管理》，规划教材，人民卫生出版社，2024
《老年护理学》北京大学医学出版社，2024
《Geriatrics Models of Care（Second Edition）》，Springer, 2024
《老年病学》英文改编版，科学出版社，2020；
《老年医学》人民卫生出版社，2019
《医院教学》人民卫生出版社，2022
《实用循证医学》人民卫生出版社，2018
《老年护理手册》科学出版社，2015
获奖及荣誉
老年失能防控关键技术体系建立和数字医养场景应用，华夏医学科技奖二等奖，2024年，第三完成人
2018年5月，参与项目“衰老与老年功能促进创新研究及成果转化”，获四川省科学技术进步奖二等奖；主要完成人
2018年12月，参与项目“衰老与老年功能促进创新研究及成果转化”，获中华医学科技奖三等奖；主要完成人
2023年5月，获四川大学华西护理学院“四川大学护理学科标志性成果奖”
2022年5月，获四川大学华西护理学院“四川大学护理学科标志性成果奖”
2020年5月，获四川大学华西护理学院“四川大学护理学科标志性成果奖”
Scientific Research Projects:
1. “The Effect and Mechanisms of Sleep-disordered Breathing on Postoperative Delirium and Cognitive Impairment”
Project No.: 81800092, National Natural Science Foundation of China, Budget: RMB 210,000, Duration: Jan 2019 – Dec 2021
2. “Application and Mechanism of Transcranial Alternating Current Stimulation in Middle-aged and Older Patients with Sleep Disorders”
Project No.: 82270106, National Natural Science Foundation of China, Budget: RMB 520,000, Duration: Jan 2023 – Dec 2026
3. “Targeting and Validating the Efficacy of Novel Transcranial Alternating Current Stimulation (tACS) for the Treatment of Chronic Insomnia”
Project No.: 20212D0201905-3, Brain Science and Brain-like Research Major Project of the Ministry of Science and Technology, Budget: RMB 1,200,000, Duration: Dec 2021 – Dec 2025
4. “Effects of Specialized Monitoring Techniques and Immediate Intervention Technology on Perioperative Outcomes and Long-term Prognosis in Older Patients”
Project No.: 2018YFC2001802-1, Ministry of Science and Technology, Budget: RMB 400,000, Duration: Dec 2018 – Dec 2022
5. “Investigation of an Interactive Games-Based System for Cognition Assessment and Decision-making in Older Adults”
Project No.: 2022YFH0074, International Science and Technology Innovation Cooperation Project, Science & Technology Department of Sichuan Province, Budget: RMB 300,000, Duration: Jan 2022 – Dec 2023
6. “The Effect of Obstructive Sleep Apnea on Perioperative Neurocognitive Function in Older Patients Undergoing Abdominal Surgery and Involved Mechanism”
Project No.: 20PJ022, Health Commission of Sichuan Province, Budget: RMB 20,000, Duration: Jan 2020 – Dec 2021
7. “Impact of Obstructive Sleep Apnea on Perioperative Neurocognitive Function and Related Mechanisms in Older Patients with Abdominal Surgery”
Project No.: 2020H1X1BH020, Postdoctoral Funding Project of West China Hospital, Budget: RMB 150,000, Duration: Sep 2020 – Aug 2022
8. “Risks and Management of Respiratory Diseases Caused by Air Pollution in Sichuan—Based on Outpatient and Emergency Information from a Super Large General Hospital”
Project No.: 2018ZR0007, Science & Technology Department of Sichuan Province, Budget: RMB 300,000, Duration: Jan 2018 – Dec 2019
9. “The Screening of Sleep Disorders in Inpatient Elderly Patients and the Development of an Evidence-Based Management Model”
Project No.: 17PJ281, Health Commission of Sichuan Province, Budget: RMB 5,000, Duration: 2017 – 2019
10. “Reforming and Exploring the Training Mode for High-level Compound Medical Talents—A Case Study of West China School of Clinical Medicine, Sichuan University”
Project No.: GSSCU2023098, Graduate Education and Teaching Reform Research Project of Sichuan University, Budget: RMB 6,000, Duration: Dec 2023 – Dec 2025
Publications:
1. Yanyan Wang, Jirong Yue, Dongmei Xie, Carter P, Li Q L, Gartaganis S L, Chen J & Sharon K. Inouye. Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and Function in Older Adults: A Randomized Clinical Trial. JAMA Internal Medicine, 2020, 180(1): 17-25.
Cited by 2 guidelines:
1) Melloul, E, Hübner, M, Scott, M et al. Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations. World J Surg, 2016.
2) Oodit, R, Biccard, BM, Panieri, E et al. Guidelines for Perioperative Care in Elective Abdominal and Pelvic Surgery at Primary and Secondary Hospitals in Low–Middle-Income Countries (LMIC’s): Enhanced Recovery After Surgery (ERAS) Society Recommendation. World J Surg, 2022.
2. He Q1, Ji L1, Wang Y1, Zhang Y1, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T. Acetate enables metabolic fitness and cognitive performance during sleep disruption. Cell Metabolism. 2024 Aug 12:S1550-4131(24)00290-0.
3. Xinrong Zuo1, Rui Zhao1, Minming Wu1, Yanyan Wang1, Shisheng Wang, Kuo Tang, Yang Wang, Jie Chen......Tao Li*. Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target. Nature Aging, 2024 Dec, Accepted
4. Shi Y, Tian X, Li T, Hu Y, Xie Y, Li H, Li Y, Jiang N, Tang X, Wang Y*. The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study. Sleep Med. 2024 Dec 9;126:185-193. doi: 10.1016/j.sleep.2024.12.011.
5. Xie, Y., Xia, X., Tian, X. et al. The association between cognitive impairment and oral health or oral hygiene behaviors among multiethnic older adults in Western China: a cross-sectional multicenter study. BMC Public Health (2024). https://doi. 10.1186/s12889-024-21158-5
6. Wu W, Pu L, Hu X, Chen Q, Wang G, Wang Y*. Moderate-to-high risk of obstructive sleep apnea with excessive daytime sleepiness is associated with postoperative neurocognitive disorders: a prospective one-year follow-up cohort study. Frontiers in neuroscience, 2023, 17.
7. Li Y, Xia X, Wu W, Tian X, Hu Y, Dong B, Wang Y*. The Mediating Effects of Nutritional Status on the Relationship between Number of Residual Teeth and Cognitive Function among Older Adults: A Cross-Sectional Multicenter Study. Nutrients, 2023, 15(14), 3089.
8. Ye, W., Han, K., Xie, M., Li, S., Chen, G., Wang, Y.,* & Li, T.* (2024). Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets. Chinese medical journal, 137(8), 936–948.
9. Fan M, Tang L, Song H, Wang Y*. Foramen ovale thrombus found during extracorporeal left ventricular assist device implantation. Asian Journal of Surgery, 2024, 1015-9584.
10. Lan X, Fan M, Peng W, Wang Y*. Adductor canal block versus femoral canal block for total knee arthroplasty: A meta-analysis of randomized controlled trials. Asian Journal of Surgery, 2023,46(11): 5094-5095.
11. Wang Y, Cheng C, Moelter S, et al. One Year of Continuous Positive Airway Pressure Adherence Improves Cognition in Older Adults with Mild Apnea and Mild Cognitive Impairment. Nursing Research, 2020, 69(2): 157-164.
12. Richards KC, Wang YY, Jun J, Ye L. A Systematic Review of Sleep Measurement in Critically Ill Patients. Frontiers in Neurology. 2020, 11: 542529.
13. Richards K, Morrison J, Wang YY, et al. Nighttime Agitation and Restless Legs Syndrome in Persons with Alzheimer's Disease: Study Protocol for a Double-Blind, Placebo-Controlled, Randomized Trial (NightRest). Research In Gerontological Nursing, 2020, 13(6): 280-288.
14. Huang Kai-Sen, Wang Yan-Yan, Deng Xiao-Jan, et al. Acute changes in hs-cTnI in an exercise test setting: a clinical tool for risk stratification in exercise-based cardiac rehabilitation. International Journal of Clinical and Experimental Medicine, 2020, 13(3): 1767-1775.
15. Wenting Li, Lun Tan, Zhixiong Zhang…Yanyan Wang*. The X-ray structure of tubulysin analogue TGL in complex with tubulin and three possible routes for the development of next-generation tubulysin analogues. Biochemical and Biophysical Research Communications. 2021, 565:29-35.
16. Lei JH, Ma LL, Xian JH… Wang YY*, Wang YX*. Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design. RSC advances, 2021, 11, 18938-18944.
17. Zhixiong Zhang, Guan Wang, Yuyan L…Yanyan Wang *, Jinliang Yang*. Recent progress in DNA methyltransferase inhibitors as anticancer agents. Frontiers In Pharmacology, 2022, 13: 1072651.
18. Richards KC, Allen RP, Morrison J…Wang Y, et al. Nighttime Agitation in Persons with Dementia as a Manifestation of Restless Legs Syndrome. Journal of the American Medical Directors Association, 2021, 22(7): 1410-1414.
19. Kai-Sen Huang, Debarati…Yan-Yan Wang, et al. Disability-Adjusted Life Years (DALYs) Due to Ischemic Heart Disease (IHD) Associated with Natural Disasters: A Worldwide Population-Based Ecological Study. Global Heart, 2021, 16(1): 30.
20. Richards KC, Gooneratne N, Dicicco B, Hanlon A, Moelter S, Onen F, Wang Y, et al. CPAP Adherence May Slow 1-Year Cognitive Decline in Older Adults with Mild Cognitive Impairment and Apnea. Journal of the American Geriatrics Society, 2019, 67(3):558-564.
21. Zhao Y, Xia X, Xie D, Liao Y, Wang Y, et al. Geriatric Nutritional Risk Index can predict postoperative delirium and hospital length of stay in elderly patients undergoing non-cardiac surgery. Geriatrics & Gerontology International, 2020, 20(8): 759-764.
22. Zhao Y, Ge N, Xie D, Gao L, Wang Y, et al. The geriatric nutrition risk index versus the mini-nutritional assessment short form in predicting postoperative delirium and hospital length of stay among older non-cardiac surgical patients: a prospective cohort study. BMC Geriatrics, 2020; 20(1): 107.
23. Wang YY, Liao YL, Gao LL, et al. [Localization Establishment of an Interdisciplinary Intervention Model to Prevent Post-Operative Delirium in Older Patients Based on 'Hospital Elder Life Program']. Hu Li Za Zhi, 2017, 64(3): 33-42.
24. Pretorius K, Cengiz A, Geshell L…Wang Y, et al. What Bed Size Does a Patient Need?: The Relationship Between Body Mass Index and Space Required to Turn in Bed. Nursing Research, 2018, 67(4): 273-274.
25. Rong Ren, Naima Covassin…Yanyan Wang, et al. Objective but Not Subjective Short Sleep Duration Is Associated With Hypertension in Obstructive Sleep Apnea. Hypertension, 2018, 72:610-617.
26. Liao Y, Flaherty JH, Yue J, Wang Y, et al. The incidence of delirium after cardiac surgery in the elderly: protocol for a systematic review and meta-analysis. BMJ Open, 2017, 7(3): e014726.
27. Zhixiong Zhang, Chengdi Wang, Lingling Ma…Yanyan Wang, et al. Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design. Biochemical And Biophysical Research Communications. 2019, 511(2): 381-386.
28. Dongmei Xie, Yulin Liao… Yanyan Wang, Chuanyao Deng, Ling Chen. Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis. BMJ open, 2018, 8(3):1-10.
29. Tingting Liu, Dongmei Wu, Jing Wang … Yanyan Wang. Validating the information-motivation-behavioral skills model of diabetes self-management among Chinese adults with type 2 diabetes: A longitudinal study, BMJ open, 2018, 8(10).
30. Cheng J, Wu Y, Wang Y, et al. Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design. Biochemical And Biophysical Research Communications, 2018, 495(1): 185-188.
31. Wang Y, Pu L, Li Z, et al. Hypoxia-Inducible Factor-1α Gene Expression and Apoptosis in Ischemia-Reperfusion Injury: A Rat Model of Early-Stage Pressure Ulcer. Nursing Research, 2016, 65(1): 35-46.
32. Jiang LP, Tu Q, Wang Y, et al. Ischemia-reperfusion injury-induced histological changes affecting early stage pressure ulcer development in a rat model. Ostomy Wound Manage, 2011, 57(2): 55-60.
ChChinese (Indexed in Medline or Chinese Science Citation Database):
33. Yuexia Hu, Xin Xia…Yanyan Wang*. Analysis of the relationship of COVID-19 vaccination and critical cases of inpatients infected with Omicron variants. Chinese Journal of Evidence-Based Medicine, 2024
34. Yi Zheng, Xiankun Sun…Yanyan Wang*. Research progress on the application of regional citrate anticoagulation in continuous renal replacement therapy patients with hyperlactatemia. Chinese Journal of Nephrology, 2024
35. Chunlin Du, Zheng Tang…Yanyan Wang*. Effectiveness analysis of chronic disease continuous health management services based on a patient satisfaction survey. West China Medical Journal. 2023, 38(04):487-493.
36. Zheng Tang, Wei Li… Yanyan Wang*, Li Ma*. Construction and practice of information platform for Internet+NCDs continuous health management mode. China Digital Medicine. 2023, 18(3):20-26.
37. Shiqi Chen, Yanyan Wang, et al. Particulate Matters and Non-accidental Emergency Visits in West China Hospital: a Time-Series Study. Journal of Sichuan University (Medical Sciences). 2019, 50 (1):71-76.
38. Yanyan Wang, Chuanyao Deng, et al. Development and validation of the China Leisure Time Physical Activity Questionnaire in the elderly. Practical Geriatrics. 2019, 33(3): 229-233.
39. Chuanyao Deng, Yanyan Wang, Dongmei Xie, et al. Effects of Hospital Elder Life Program-based interdisciplinary intervention on prevention of postoperative delirium in the elderly. Practical Geriatrics. 2019, 33(1): 12-15.
40. Ling Chen, Jirong Yue, Langli Gao, Yanyan Wang*. Preliminary validation and feature word extraction of the electronic medical record evaluation delirium scale. Journal of Sichuan University (Medical Sciences). 2019,50(1): 136-138.
41. Yulin Liao, Dongmei Xie, Jirong Yue, Yanyan Wang, et al. Analysis of the incidence and risk factors of postoperative delirium in the elderly after non-cardiac surgery. Practical Geriatrics. 2019, 33(2): 115-120.
42. Xiuying Hu, Chunlan Bai…Yanyan Wang, et al. Investigation on the full range of health care model for older people under the rapid aging process. Chinese Nursing Management. 2018, 18(5): 590-596.
43. Yunxia Zhang, Xiaoyan Chen, Yanyan Wang, et al. Reliability and validity analysis of the Adult Disability Assessment Tool Scale. Journal of Sichuan University (Medical Sciences). 2018, 49(5): 789-792.
44. MeiR Fu, Yali Tian, Xianqiong Feng…Yanyan Wang, et al. Application fields and development directions of precision nursing. Chinese Journal of Nursing. 2017, 52(10): 1273-1275.
45. Yanyan Wang, Yulin Liao, Jirong Yue. Research on the mechanism of delirium based on related serum biomarkers of the delirium. JOURNAL OF BIOMEDICAL ENGINEERING. 2017 (3): 465-470.
46. Yanyan Wang, Jirong Yue, Xiuying Hu. Research progress of post-operative delirium on elderly patients. Chinese Journal of Practical Nursing. 2015, 31(27): 2097-2100.
47. Zhi Li, Yanyan Wang, Xiuying Hu. The progress of information management in evidence-based nursing practice: a literature review. Chinese Nursing Management, 2015, 15(10): 1268-1270.
48. Yanyan Wang, Ruili Wang. Practice and thinking of “surgical nursing” bilingual teaching. Chinese Nursing Research, 2013, 27(10C): 3440-3442.
49. Yanyan Wang, Jia Chen, Liping Jiang. Expression and role of hypoxia inducible factor-1 α and matrix metalloproteinase-9 during early development of pressure ulcer. Journal of Nursing Science. 2012, 27(5): 3-6.
50. Yanyan Wang, Liping Jiang, et al. Investigate the expression and role of apoptosis-related proteins Bcl-2/Bax in early stage pressure ulcer. Chinese Journal of Burns. 2011, 27 (3):197-199.
51. Yanyan Wang, Chunyu Zhang, et al. The role of oxidative stress and apoptosis in the progress of early stage pressure ulcer. Chinese Journal of Nursing. 2011, 46(5): 523-525.
52. Yanyan Wang, Haiqin Sun, et al. Establishing and Evaluation of an Animal Model of Early Stage Pressure Ulcer, Journal of Nursing Science, 2010, 25(14): 1-5.
53. Yanyan Wang, Liping Jiang, et al. Biomechanical, Cyclic and Metabolic Progress of Pressure Ulcer. Journal of Nursing Science, 2010, 25(8):93-96.
54. Liping Jiang, Yanyan Wang, Chunyu Zhang, Yan Sun. Activity of adenosine triphosphatase and the expression of ryanodine receptor 1 mRNA in local tissue of pressure ulcer at early stage in gracilis of rats. Chinese Journal of Burns. 2011, 27(03):178-182.
55. En Zhang, Qian Tu, Yanyan Wang, et al. Apoptosis mediated by Fas/FasL in Ⅲ-stage pressure ulcers and its role in ulcer healing. Chinese Journal of Pathophysiology, 2010, 26(5): 1006-1008.
Books Contributed :
l "Home and Community-Based Geriatric Care Management," Planning Textbook, People's Health Press, 2024
l "Geriatric Nursing," Peking University Medical Press, 2024 "Geriatrics Models of Care (Second Edition)," Springer, 2024
l "Geriatrics: An English Adaptation," Science Press, 2020;
l "Geriatrics Medicine," People's Health Press, 2019
l "Hospital Teaching," People's Health Press, 2022
l "Practical Evidence-Based Medicine," People's Health Press, 2018
l "Handbook of Geriatric Nursing," Science Press, 2015
Awards and Honors:
l Project “Establishment of Key Technologies for Disability Prevention in Old Age and Application in Digital Medical and Nursing Scenarios”, Huaxia Medical Science and Technology Award, Second Prize, 2024
l Project "Innovative Research on Aging and Promotion of Functions in the Elderly and Its Transformation of Achievements" Sichuan Provincial Science and Technology Progress, Second Prize, 2018
l Project "Innovative Research on Aging and Promotion of Functions in the Elderly and Its Transformation of Achievements" Chinese Medical Science and Technology Award, Third Prize, 2018.
l Honored with the "Significant Achievement Award in Nursing Science" from Sichuan University Nursing School, 2023
l Recognized with the "Significant Achievement Award in Nursing Science" from Sichuan University Nursing School, 2022
Awarded the "Significant Achievement Award in Nursing Science" by Sichuan University Nursing School,2020
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