博士，教授，博士研究生导师；2016年毕业于四川大学华西临床医学院(博士研究生)，并留院工作于华西医院老年医学中心/国家老年疾病临床医学研究中心，2017-2021年在美国德克萨斯大学奥斯汀分校(The University of Texas at Austin)完成博士后及Research Associate研究工作。现任四川大学华西医院科技部副部长。
围绕主动健康和老龄化科技应对，长期聚焦“老年睡眠与认知障碍早期精准防控”基础和临床研究，主持包括国家自然科学基金（青年/面上）及国家科技创新2030脑科学和主动健康老龄化科技应对重大/重点项目在内的国家/省部级课题9项;在各级学术刊物发表论文50余篇（SCI论文38篇），以第一和通讯作者（含共同）在JAMA Internal Medicine (中科院1区TOP, IF=22.5，独立一作)、Cell Metabolism (中科院1区TOP, IF= 27.7，封面/共一)、Nature Aging (中科院1区TOP, IF=17，共一)等医学权威期刊发表论文15篇，他引近千次（谷歌学术）；单篇最高引用178次；研究成果被哈佛大学老年医学中心主任Sharon Inouye教授、美国国立老龄化研究部主任Ken Covinsky教授等高度肯定，被JAMA、Lancet等医学顶刊及指南广泛引用。授权发明专利和软著7项，临床转化和应用6项；参编规划教材/国外专著8部/标准4部; 担任中华医学会医学科学研究管理学分会青年委员、中国睡眠研究会青年委员、中国康复医学会慢病康复专委会委员、中国医学装备协会医疗器械创新与应用分会常委、《Precision Clinical Medicine》青年编委、《International Journal of Nursing Sciences》编委等多项学术任职。 2023年入选四川省省级青年科技菁英人才；2024年获华夏医学科技奖二等奖（3/10）、四川省医学会科技推广奖二等奖（1/8）、教育部科学研究优秀成果奖二等奖（5/19）。
Professor Yanyan Wang graduated from the West China School of Medicine at Sichuan University as with a doctoral degree in 2016 and has since been engaged in the Geriatric Department and National Clinical Research Center for Geriatrics of West China Hospital, Sichuan University. From 2017 to 2021, she completed Postdoctoral Fellowship and worked as a Research Associate at The University of Texas at Austin in the United States. Currently, she is Deputy Director of the Science and Technology Department at West China Hospital, Sichuan University. Focusing on active health and technological responses to aging, Dr. Wang has dedicated herself to both basic and clinical research on "early and precise prevention and control of sleep disorders and cognitive impairment in the older adults." She has led 9 national and provincial-level projects, including those funded by the National Natural Science Foundation of China (Youth/General) as well as Major/Key Projects under China's National Science and Technology Innovation 2030 initiative concerning Brain Science and Technological Responses to Active Health Aging. To date, she has published over 50 papers across various academic journals (38 indexed in SCI), including JAMA Internal Medicine (IF=22), Cell Metabolism (IF=27.7; cover/featured article) and Nature Aging (IF=17). Her work has been widely cited and commented by high impact medical journals and guidelines such as JAMA and Lancet. Seven invention patents and software Copyrights have been authorized, and six have been clinically transformed and applied. Participated in the compilation of 8 planned textbooks/foreign monographs regarding with Geriatrics or Gerontology, as well as 4 standards for long-term care. Dr. Wang has been selected as a young science and technology talent in Sichuan Province in 2023. In 2024, she won the Second Prize of the Huaxia Medical Science and Technology Award (3/10), and the Second Prize of the Sichuan Medical Association Science and Technology Promotion Award (1/8).
l 中华医学会医学科学研究管理学分会 青年委员
l 中国医学装备协会医疗器械创新与应用分会 常委
l 中国康复医学会慢病康复专业委员会 第一届委员会委员
l 中国睡眠研究会青年工作委员会 第二届青年委员
l 第三届四川省医学会转化医学专委会常委
l SCI 杂志《Journal of Nursing Scholarship》(ISSN1527-6546)中文版 编委兼秘书长
l ESCI 杂志《Precision Clinical Medicine》(ISSN 2096-5303)青年编委
l ESCI 杂志《International Journal of Nursing Sciences》(ISSN 2096-6296)编委
l Young member of the Medical Science Research Management Branch of the Chinese Medical Association
l Standing committee member of the Medical Device Innovation and Application Branch of the China Association of Medical Equipment
l Member of the First Committee of the Chronic Disease Rehabilitation Professional Committee of the Chinese Association of Rehabilitation Medicine
l Youth Member of the Second Youth Committee of the Chinese Sleep Research Society
l Standing Committee Member of the Translational Medicine Committee of the Third Sichuan Medical Association
l Editorial board member and Secretary-General of Journal of Nursing Scholarship (Chinese version) (ISSN1527-6546)
l Youth Editorial Board Member of Precision Clinical Medicine (ISSN 2096-5303)
l Editorial board member of International Journal of Nursing Sciences(ISSN 2096-6296)
主持国家级/省部级项目/Grants (Principal Investigator )
1. 睡眠呼吸障碍对术后谵妄和认知功能损害的影响及机制研究（81800092）. 国家自然科学基金青年项目，21万，2019.01-2021.12,
“The Effect and Mechanisms of Sleep-disordered Breathing on Postoperative Delirium and Cognitive Impairment”(Project No.81800092), National Natural Science Foundation of China, RMB 210,000, 2019.01-2021.12, Principal Investigator
2. 经颅电刺激在中老年人失眠合并阻塞性睡眠呼吸暂停中的应用及机制探讨（82270106）国家自然科学基金面上项目. 52万，2023.01-2026.12
“Application and Mechanism of Transcranial Alternating Current Stimulation in Middle-aged and Older Patients with Sleep Disorders” (Project No.82270106), National Natural Science Foundation of China, RMB 520,000, Jan 2023-Dec 2026, Principal Investigator
3. 国家科技部脑科学与类脑研究重大项目-睡眠障碍的发病机制及干预技术研究，子课题-探索新型tACS治疗慢性失眠障碍的靶点与疗效验证（2021ZD0201905-3）; 2021.12.31-2026.12.31. 120万（总经费5960万）
“Targeting and Validating the Efficacy of Novel Transcranial Alternating Current Stimulation (tACS) for the Treatment of Chronic Insomnia”(Project No.20212D0201905-3), Brain Science and Brain-like Research Major Project of the Ministry of Science and Technology, RMB 1,200,000, Dec 2021-Dec 2026, Principal Investigator
4. 国家科技部重点研发计划，特殊监测手段和即时干预技术对老年围术期转归和远期预后的影响-1(2018YFC2001802-1)，2018.12.01-2022.12.31, 负责人，总经费480万（子课题40万）
“Effects of Specialized Monitoring Techniques and Immediate Intervention Technology on Perioperative Outcomes and Long-term Prognosis in Older Patients”(Project No. 2018YFC2001802-1), Ministry of Science and Technology, RMB 400,000, Dec 2018-Dec 2022, Principal Investigator
5. 基于交互式游戏的老年认知功能评估与决策研究（2022YFH0074）. 四川省科技厅国际科技创新合作项目，30万，2022.1-2023.12
“Investigation of an Interactive Games-Based System for Cognition Assessment and Decision-making in Older Adults”(Project No.2022YFH0074), International Science and Technology Innovation Cooperation Project, Science & Technology Department of Sichuan Province, RMB 300,000, Jan 2022-Dec 2023, Principal Investigator
6. 四川地区大气污染致呼吸系统疾病的发病风险及管理研究—基于超大型医院门急诊信息 (2018ZR0007). 四川省科技厅软科学重点项目，30万，2018.1-2019.12, 结题
“Risks and Management of Respiratory Diseases Caused by Air Pollution in Sichuan—Based on Outpatient and Emergency Information from a Super Large General Hospital”(Project No.2018ZR0007), Science & Technology Department of Sichuan Province, RMB 300,000, Jan 2018-Dec 2019, Principal Investigator
7. 四川省“天府青城计划”人才项目，20万，2024-2028.
Sichuan Province's "Tianfu Qingcheng Program" Talent Project, RMB 200,000, 2024-2028, Principal Investigator
美国博士后期间参与NIH项目/Postdoc Fellowship Grants
u Postdoc & Research Associate
1) Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep Apnea (Memories 2) (NIH grant NIA R01AG054435), 2017-2021, $9,700,000.
Administrative Supplement for Latino Recruitment, Research Sleep Studies, and Research CPAP devices; $652,087.
MPI: Gooneratne, N.S. (University of Pennsylvania), Richards, K.C. (The University of Texas at Austin).
Research associate (Postdoc throughout 10/2017-10/2019)
The primary goal of the proposed research is to determine whether treatment of obstructive sleep apnea (OSA) in older adults with mild cognitive impairment delays cognitive decline and preserves everyday function. Additional potential study benefits are increased understanding of the physiological mechanisms for cognitive decline in oaMCI and OSA, and the characteristics of those most likely to benefit from this treatment.
2) Nighttime Agitation and Restless Legs Syndrome in Persons with Alzheimer’s Disease
(NIH grant NIA R01AG051588-01A1), 2016-2021, $3,815,876.
PI: Kathy C. Richards, PhD, RN
Research associate (Postdoc throughout 10/2017-10/2019)
The purpose of this pilot clinical trial is to determine whether restless legs syndrome is a mechanism for nighttime agitation in Alzheimer’s Disease patients, and if treatment with gabapentin enacarbil (Horizant®) reduces nighttime agitation, improves sleep, reduces restless legs syndrome behaviors, and reduces antipsychotic medications.
3) Mild Cognitive Impairment and Obstructive Sleep Apnea (Memories 1) -Completed
(NIH grant NIA R01 AG034682-03), 2011-2014, $1,903,463.
PI: Kathy C. Richards, PhD, RN
Postdoc throughout 10/2017-10/2019
The purpose of this pilot clinical trial in older adults with mild cognitive impairment (MCI) and obstructive sleep apnea (OSA) is to determine the effects of continuous positive airway pressure on cognitive and everyday function in persons with mild cognitive impairment. This project has been finished, and I worked on writing and submitting the manuscripts, as well as secondary analysis.
近期代表论文/Publications
1. Yanyan Wang, Jirong Yue, Dongmei Xie, Carter P, Li Q L, Gartaganis S L, Chen J & Sharon K. Inouye. Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and Function in Older Adults: A Randomized Clinical Trial. JAMA Internal Medicine, 2020, 180(1): 17-25.
2. He Q1, Ji L1, Wang Y1, Zhang Y1, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T. Acetate enables metabolic fitness and cognitive performance during sleep disruption. Cell Metabolism. 2024Sep 3;36(9):1998-2014.
3. Xinrong Zuo1, Rui Zhao1, Minming Wu1, Yanyan Wang1, Shisheng Wang, Kuo Tang, Yang Wang, Jie Chen, Xiaoxiang Yan* , Yang Cao*, Tao Li*. Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target. Nature Aging, 2025,Mar;5(3):419-436.
4. Shi Y, Tian X, Li T, Hu Y, Xie Y, Li H, Li Y, Jiang N, Tang X, Wang Y*. The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study. Sleep Med. 2024, Dec 9;126:185-193.
5. Xie, Y., Xia, X., Tian, X. Yanyan Wang*. The association between cognitive impairment and oral health or oral hygiene behaviors among multiethnic older adults in Western China: a cross-sectional multicenter study. BMC Public Health.2024,25(1):259.
6. Ye, W., Han, K., Xie, M., Li, S., Chen, G., Wang, Y.,* & Li, T.* (2024). Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets. Chinese medical journal, 137(8), 936–948.
7. Wu W, Pu L, Hu X, Chen Q, Wang G, Wang Y*. Moderate-to-high risk of obstructive sleep apnea with excessive daytime sleepiness is associated with postoperative neurocognitive disorders: a prospective one-year follow-up cohort study. Frontiers in neuroscience, 2023, 17.
8. Li Y, Xia X, Wu W, Tian X, Hu Y, Dong B, Wang Y*. The Mediating Effects of Nutritional Status on the Relationship between Number of Residual Teeth and Cognitive Function among Older Adults: A Cross-Sectional Multicenter Study. Nutrients, 2023, 15(14), 3089.
9. Xiong, Y., Liu, X., Jiang, L., Hao, T., Wang, Y. *& Li, T. Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice. Journal of translational medicine, 2024，22(1), 199.
10. Hu, Y., Xia, X., Li, H., Xie, Y., Tian, X., Li, Y., Yue, J., Dong, B., & Wang, Y*. (2025). The association between sleep quality and cognitive impairment among a multi-ethnic population of middle-aged and older adults in Western China: a multi-center cross-sectional study. Frontiers in public health, 13, 1500027. https://doi.org/10.3389/fpubh.2025.1500027
11. Tian, X., Xia, X., Li, H., Hu, Y., Xie, Y., Hu, X., Yue, J., Dong, B., Wu, B., & Wang, Y*. (2025). Mediation of nutritional status between the number of teeth and depressive symptoms in multi-ethnic older adults from Western China. Frontiers in public health, 13, 1506640.
12. Zheng, Y., Chen, Z., Sun, X., Wang, F., Tang, X., Lin, L., Wang, Y.,* & Zhang, L*. (2025). Development and Validation of a Risk Prediction Model for Citrate Accumulation in Patients Undergoing Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation. Blood purification, 1-14. Advance online publication.
13. Wang Y, Cheng C, Moelter S, et al. One Year of Continuous Positive Airway Pressure Adherence Improves Cognition in Older Adults with Mild Apnea and Mild Cognitive Impairment. Nursing Research, 2020, 69(2): 157-164.
14. Wang, YY; Cheng, C; Gooneratne, N; Carter, P; Richards, K. ONE YEAR OF CPAP ADHERENCE IMPROVES COGNITION IN OLDER ADULTS WITH MILD APNEA AND MILD COGNITIVE IMPAIRMENT. SLEEP, 2019, 42: 1.
15. Fan M, Tang L, Song H, Wang Y*. Foramen ovale thrombus found during extracorporeal left ventricular assist device implantation. Asian Journal of Surgery, 2024, 1015-9584.
16. Lan X, Fan M, Peng W, Wang Y*. Adductor canal block versus femoral canal block for total knee arthroplasty: A meta-analysis of randomized controlled trials. Asian Journal of Surgery, 2023,46(11): 5094-5095.
参编教材/专著/Chapters
l 《居家社区养老护理管理》国家卫生健康委“十四五”规划教材“第五章 居家社区养老服务内容”, 人民卫生出版社，2024
l 《老年护理学》全国高等教育自学考试指定教材“第六章 老年综合征及其护理”, 北京大学医学出版社，2024
l 《老年病学》中国科学院教材建设专家委员会规划教材/医学英文原版改编双语教材“Chapter 15 Sleep Disorders”, 科学出版社，2020
l 《护理学研究方法》第3版国家卫生健康委“十四五”规划教材及数字资源（研究生）“第五篇第二十五章护理相关科研基金的类别及第二十六章护理科研项目的管理”人民卫生出版社，定稿待出版
l 《Geriatrics Models of Care（Second Edition）》“Part I Hospital Based Models of Care”Springer, 2024
l 《医院教学》“第三章第8节 远程医疗实践教学”, 人民卫生出版社，2021
l 《老年医学》“第九章第9节 睡眠障碍”, 人民卫生出版社，2019
l 《实用循证医学》“第十五章第6节 跌倒”, 人民卫生出版社，2018
l 《Home and Community Elderly Care Nursing Management》, National Health Commission's "Textbooks for the 14th Five-Year Plan" , "Chapter Five: Contents of Home and Community Elderly Care Services", People's Medical Publishing House, 2024
l 《Geriatric Nursing》, National Higher Education Self-study Examination Designated Textbook, "Chapter VI Geriatric Syndrome and Its Nursing", Peking University Medical Press, 2024
l 《Geriatrics》, a bilingual textbook adapted from the original medical English version, planned by the Expert Committee for Textbook Construction of the Chinese Academy of Sciences, "Chapter 15 Sleep Disorders", Science Press, 2020
l 《Nursing Research Methods》, 3rd Edition, National Health Commission's "14th Five-Year Plan" Textbook and Digital Resource (for Postgraduate students), "Chapter 25 of Part 5: Categories of Nursing-related Research Funds and Chapter 26: Management of Nursing Research Projects", People's Medical Publishing House, finalized for publication
l 《Geriatrics Models of Care (Second Edition)》 "Part I Hospital Based Models of Care" Springer, 2024
l 《Hospital Teaching》"Chapter 3, Section 8: Remote Medical Practice Teaching", People's Medical Publishing House, 2021
l 《Geriatrics》“Chapter 9, Section 9 Sleep Disorders", People's Medical Publishing House, 2019
l 《Practical Evidence-Based Medicine》"Chapter 15, Section 6: Falling", People's Medical Publishing House, 2018
参编标准/Standards contribution
《成都市长期照护保险成人失能综合评估规范》(DB5101/T 60-2019)；
中国研究型医院学会《成人术后谵妄评估规范》(T/CRHA 142-2025)
四川省护理学会《老年照护服务标准》(T/SCNA 001-2021)
《老年照护服务质量评价标准》(T/SCNA 002-2021)
l "Comprehensive Assessment Specification for Adult Disability of Long-Term Care Insurance in Chengdu City" (DB5101/T 60-2019)
l "Evaluation Criteria for Postoperative Delirium in Adults" of the Chinese Society of Research Hospitals (T/CRHA 142-2025)
l "Service Standards for Elderly Care" of Sichuan Nursing Association (T/SCNA 001-2021)
l "Evaluation Standard for Quality of Elderly Care Services" (T/SCNA 002-2021)
获奖/荣誉Awards/Honors
· 2023年12月，入选“天府QC”青年科技人才
· 2024年12月，项目“老年失能防控关键技术体系建立和数字医养场景应用”获华夏医学科技奖二等奖(3/10)
· 2024年12月，项目“老年失能防控关键技术体系构建和智慧化推广应用”获四川省医学会科技推广奖一等奖(1/8)
· 2018年，项目“衰老与老年功能促进创新研究及成果转化”，获四川省科学技术进步奖二等奖及中华医学科技奖三等奖(6/12)
l "Tianfu Qingcheng Program" for young scientific and technological talents, 2023
l Project "Establishment of a Key Technology System for the Prevention and Control of Elderly Disability and Application of Digital Medical and Elderly Care Scenarios" , the second prize of the Huaxia Medical Science and Technology Award, 2024
l Project "Construction of Key Technology System for Elderly Disability Prevention and Control and Intelligent Promotion and Application" , the first prize of Science and Technology Promotion Award of Sichuan Medical Association, 2024
Project "Innovative Research and Transformation of Achievements on Aging and Elderly Function Promotion" , the second prize of Sichuan Provincial Science and Technology Progress Award & the third Prize of the Chinese Medical Science and Technology Award, 2018
研究生部公众号
川公网安备51010702002012