周西坤，博士，研究员，博士研究生导师，国家级青年人才，四川大学生物治疗全国重点实验室独立PI。主持国家自然科学基金和“四大慢病”科技重大专项等多项国家级基金项目，申报中国发明专利5项，累计发表高水平国际期刊学术论文60余篇，以第一或通讯作者（含共同）在Nature Microbiology、Nature Communications、Signal Transduction and Targeted Therapy等国际知名期刊上发表论文40余篇。
长期致力于人类重大疾病生物治疗的前沿基础研究与临床转化探索，重点关注病原细菌呼吸道感染的致病机制、宿主免疫应答与创新药物研发这一重大科学方向。团队以临床危害严重的铜绿假单胞菌为核心研究对象，利用基因工程动物模型与临床样本，整合免疫学、细胞生物学与系统生物学多学科手段，深入揭示病原细菌定植演化与免疫逃逸的分子调控网络。团队在慢性感染形成机制（揭示TesG毒力蛋白抑制宿主先天免疫从而促进慢性感染）与新药靶点发现（以群体感应系统关键蛋白LasR为靶点的“群体淬灭”抗感染新策略）等方面取得系列原创成果。
研究工作始终围绕临床亟待解决的核心难题展开——包括耐药铜绿假单胞菌所致慢性呼吸道感染的精准诊断与有效治疗，旨在开发基于分子标志物的早期预警体系和靶向群体淬灭的新型抗感染药物，推动生物治疗技术及基因诊断策略在临床的实质性转化与应用，为攻克感染性重大疾病提供原创策略。
担任Journal of Cellular and Molecular Medicine副主编，Journal of Molecular Medicine编委，hLife和Fundamental Research青年编委。
中国疫苗行业协会细菌感染与疫苗研究专业委员会等学会委员。
【近期代表论文】
1. Tang M†, Zhang Y†, Xie R†, Wu T†, Sun P, Luo Y, Wang R, Ma T, Yang YY, Zhang Y, Zou C, Hu X, Li JS, Liu H, Liu Z, Zhang Q, Tang Y, Li H, Liu Y, Yang Y, Li J, Bian C*, Tang Y*, Zhou X*. Circular RNA circMagi1 regulates the host immune response in respiratory Pseudomonas aeruginosa infection through G3BP2. mBio. 2026;17(4):e0361725.
2. Zhang Y†, Tang M†, Xie R†, Yang Y, Sun P, Luo Y, Wang R, Hu X, Ma T, Zhang Y, Zou C, Liu H, Wu M, Ren Y, Li H, Li J, Bian C*, Tang Y*, Zhou X*. Identification of circSlc7a11, a Novel circRNA that Functions as a Negative Regulator of Host Immune Defense Against Pulmonary Pseudomonas aeruginosa Infection. American Journal of Respiratory Cell and Molecular Biology. 2026;74(3):339–49.
3. Zhang Q†, Zhang Y†, Wang R†, Wang K†, Ma T, Zou C, Zhang Y, Hu X, Liu H, Li JS, Yang Y, Liu Z, Tang M, Liu Y, Li H, Tang Y, Li J, Zhou X*. The Pseudomonas aeruginosa effector protein TesG regulates alternative activation of macrophages through NLRC5. mSphere. 2025;10(11):e0068125.
4. Li R, Li J*, Zhou X*. Lung microbiome: new insights into the pathogenesis of respiratory diseases. Signal Transduction and Targeted Therapy. 2024;9(1):19.
5. Zhao K*, Yang X, Zeng Q, Zhang Y, Li H, Li J, Liu H, Du L, Huang G, Zhang Y, Chu Y*, Zhou X*. Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung. Nature Communications. 2023; DOI: 10.1038/s41467-023-41704-w.
6. Ma T†, Tang Y†, Wang T, Yang Y, Zhang Y, Wang R, Zhang Y, Li Y, Wu M, Tang M, Hu X, Zou C, Ren Y, Liu H, Zhang Q, Li H, Wu M, Li J*, Zhou X*. Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis with tumor-promoting MHCIIhi neutrophils. Signal Transduction and Targeted Therapy. 2023;8(1):296.
7. Yang Y†, Ma T†, Zhang Y, Zhang J, Li J*, Li T*, Zhou X*. An integrated multi-omics analysis of identifies distinct molecular characteristics in pulmonary infections of Pseudomonas aeruginosa. PLOS Pathogens. 2023;19(8):e1011570.
8. Hu X†, Wu M†, Ma T, Zhang Y, Zou C, Wang R, Zhang Y, Ren Y, Li Q, Liu H, Li H, Wang T, Sun X, Yang Y, Tang M, Li X, Li J, Gao X, Li T*, Zhou X*. Single-cell transcriptomics reveals distinct cell response between acute and chronic pulmonary infection of Pseudomonas aeruginosa. MedComm. 2022;3(4):e193.
9. Zhao K*, Li J, Yang X, Zeng Q, Liu W, Wu Y, Zhou H, Prithiviraj B, Wang X, Zhou X*, Chu Y*. Subinhibitory Cefotaxime and Levofloxacin Concentrations Contribute to Selection of Pseudomonas aeruginosa in Coculture with Staphylococcus aureus. Applied and Environmental Microbiology. 2022;88(12):e0059222.
10. Zhao K, Li W, Li Jin, Ma T, Wang K, Yuan Y, Li S-J, Xie R, Huang T, Zhang Y, Zhou Y, Huang N, Wu W, Wang Z, Zhang J, Yue B, Zhou Z, Li Jio, Wei Y-Q, Zhang X*, Zhou X*. TesG is a type I secretion effector of Pseudomonas aeruginosa that suppresses the host immune response during chronic infection. Nature Microbiology. 2019;4(3):459-469.
详细论文列表请见：
https://scholar.google.com/citations?hl=en&user=b4NavKwAAAAJ
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