赖颖，研究员，教育部重大人才工程特聘教授，入选国家级人才项目。长期专注于囊泡转运机制的研究，围绕“囊泡转运与细胞分泌的精确调控”这一前沿科学问题，开展三个方面的工作：1，发展与建立囊泡融合技术。2，呼吸道阻塞性肺病机制研究。3，靶向粘液高分泌的药物开发。目前以通讯或第一作者在包括Nature、Nature Neuroscience、Neuron、Nature Communications、PNAS等在内的权威期刊上发表论文共计24篇。论文被正面引用3000余次。近五年以通讯作者在Nature、Nature Neuroscience、Nature Communications、Adv Sci等国际期刊发表研究论文11篇，学术成果多次被Nature、Nature Review Drug Discovery、Neuron等顶级期刊引用评论，也被全球多家媒体报道，被评为领域突破性进展。多次受邀在国际国内学术会议进行学术报告，并担任细胞生物学会、神经生物物理分会和单分子生物学分会委员。
担任细胞生物学会、神经生物物理分会和单分子生物学分会委员
担任 Nature Protocols、STTT、Nanoscale等国际权威期刊审稿人
Cell Biology International、Frontiers in Physiology等期刊担任审稿编辑
1，Li W*, Wu M*, Feng S*, Su J*, Niu Q*, Fan J, Cui L, Xiang Y, Li H, Li K, Lu G, Lai Y. (2026)Molecular Mechanism of Cholesterol-Dependent Membrane Fusion in SARS-CoV-2 Entry. Signal Transduction and Targeted Therapy. 11(1):57. doi: 10.1038/s41392-026-02573-z.
2，Cui L, Cui Y, Liu J, Li W, Wu M, Wei X, Lai Y#, Mi P#. (2025) Bioengineered nanovesicles for efficient siRNA delivery through ligand-receptor-mediated and enzyme-controlled membrane fusion. Nature Communications. 16(1):6174. doi: 10.1038/s41467-025-61230-1.
3，Pei Q*, Chen Q*, Tian Z*, Zhu L*, Chen Y*, Gong J, Wang S, Xiang Y, Khamo JS, Fan J, Rong Y, Yu Y, Qin Y, Wu S, Faragalla Y, Cao P, Zhang K#, Lai Y#, Wu LG#, Ma C#, Yang X#, Diao J#. (2025) Munc18 modulates syntaxin phase separation to promote exocytosis. Nature Neuroscience. doi: 10.1038/s41593-025-02140-9.
4，Xiang Y*, Cui L*, Yao J*, Lou X*, Wu M, Huo J, Fan J, Li H, Li K, Wang X, Shin YK, Yang X, Wang C#, Lai Y#. (2025) Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions. Nature Communications;16(1):7113.
5，Wu M*, Li W*, Lin S, Fan J, Cui L, Xiang Y, Li K, Tang L, Duan Y, Chen Z, Yang F, Shui W, Lu G, Lai Y#. (2023). A Suitable Membrane Distance Regulated by the RBD_ACE2 Interaction is Critical for SARS-CoV-2 Spike-Mediated Viral Invasion. Advanced Science. 10(28): e2301478
6，Lai Y#, Fois G, Flores JR, Tuvim MJ, Yang K, Zhou Q, Leitz J, Peters J, Zhang Y, Pfuetzner RA, Esquivies L, Jones P, Frick M#, Dickey BF#, Brunger AT#. (2022) Inhibition of Ca2+-triggered secretion by hydrocarbon-stapled peptides. Nature. 603, 949-956.
7，Lai Y*, Choi UB*, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, Brunger AT#. (2017) Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18. Neuron. 95(3): 591-607.
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